DegronMD

Uniprot ID: Q9UBU7

Source protein: Protein DBF4 homolog A

Source gene: DBF4

Class: DEG_SCF_FBW7_2

Location: 550:557

E3 ligase: FBXW7

DEGRON score: 0.9891

ASA_SCORE: 108.1875

COIL: 0.9601

CONS_SCORE: 0.4429

DSS_SCORE: 0.6008

HELIX: 0.0165

FCONS_SCORE: 1.0017

RIG_SCORE: 0.6446

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L543V	TCGA-06-A6S1	GBM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.1389
p.L543V	DO50113	GBM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.1389
p.E556D	TCGA-AP-A0LM	UCEC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.5647
p.E556D	DO43306	UCEC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.5647
p.F563V	TCGA-AP-A1E0	UCEC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.1667
p.F563V	DO43154	UCEC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.1667
p.K548N	TCGA-D3-A2J8	SKCM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.2778
p.K548N	DO37778	SKCM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.2778
p.H542D	TCGA-EE-A29S	SKCM	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.1111
p.H542D	DO37936	SKCM	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.1111
p.K564N	TCGA-JW-A5VL	CESC	TCGA	PFHTPPEE	DEG_SCF_FBW7_2	0.25
p.K564N	DO49976	CESC	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.25
p.K564N	DO234437	ESAD	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.25
p.E556Q	DO52582	BOCA	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.5633
p.D562Y	DO229045	LICA	ICGC	PFHTPPEE	DEG_SCF_FBW7_2	0.1944
p.H552R	SIDM00640	Mesothelioma	GDSC	PFHTPPEE	DEG_SCF_FBW7_2	0.7133
p.H552R	ACH-000335	Lung Cancer	CCLE	PFHTPPEE	DEG_SCF_FBW7_2	0.7133
p.H552R	MSTO-211H	pleura	COSMIC	PFHTPPEE	DEG_SCF_FBW7_2	0.7133
p.T553N	AU565	breast	COSMIC	PFHTPPEE	DEG_SCF_FBW7_2	0.8166

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBU7	Protein DBF4 homolog A	DEG_SCF_FBW7_2	550:557	PFHTPPEE	FBXW7	0.9891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons