DegronMD

Uniprot ID: Q9UBU7

Source protein: Protein DBF4 homolog A

Source gene: DBF4

Class: DEG_APCC_DBOX_1

Location: 25:33

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9994

ASA_SCORE: 101.0556

COIL: 0.8241

CONS_SCORE: 0.4909

DSS_SCORE: 0.6508

HELIX: 0.1504

FCONS_SCORE: 1.2957

RIG_SCORE: 0.7028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N25S	TCGA-F7-A624	HNSC	TCGA	NRPSLKSLK	DEG_APCC_DBOX_1	0.5958
p.N25S	DO44440	HNSC	ICGC	NRPSLKSLK	DEG_APCC_DBOX_1	0.5958
p.C43Y	DO229058	LICA	ICGC	NRPSLKSLK	DEG_APCC_DBOX_1	0.0556
p.I18N	SIDM01640	Acute Myeloid Leukemia	GDSC	NRPSLKSLK	DEG_APCC_DBOX_1	0.1389
p.I18N	ACH-000602	Leukemia	CCLE	NRPSLKSLK	DEG_APCC_DBOX_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBU7	Protein DBF4 homolog A	DEG_APCC_DBOX_1	25:33	NRPSLKSLK	APC,CDC20,FZR1	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons