DegronMD

Uniprot ID: Q9UBU7

Source protein: Protein DBF4 homolog A

Source gene: DBF4

Class: DEG_APCC_KENBOX_2

Location: 586:590

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6044

ASA_SCORE: 131.32

COIL: 0.8408

CONS_SCORE: 0.5626

DSS_SCORE: 0.3859

HELIX: 0.103

FCONS_SCORE: 1.1632

RIG_SCORE: 0.7248

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D597G	TCGA-56-8625	LUSC	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1389
p.D597G	DO45515	LUSC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1389
p.R599I	TCGA-A5-A2K5	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	0.0833
p.R599I	DO41379	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.0833
p.R576Q	TCGA-AA-3984	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	0.0556
p.R576Q	DO9002	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.R584Q	TCGA-AP-A056	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	0.2778
p.R584Q	DO233941	GACA	ICGC	RKENL	DEG_APCC_KENBOX_2	0.2778
p.R584Q	DO43971	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.2778
p.E595K	TCGA-DK-A1A6	BLCA	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1944
p.E595K	DO472	BLCA	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.R599K	TCGA-EO-A22R	UCEC	TCGA	RKENL	DEG_APCC_KENBOX_2	0.0833
p.R599K	DO42713	UCEC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.0833
p.D597N	TCGA-ZJ-AAXB	CESC	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1389
p.D597N	DO219753	CESC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1389
p.I581V	DO231091	LUSC	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.I581V	ACH-000593	Bladder Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.1944
p.N593K	ACH-001113	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.25
p.N593K	ACH-002156	Lung Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.25
p.N593K	LC-1-sq	lung	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.25
p.E591K	ACH-002287	Colon/Colorectal Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.3056
p.E591K	NCI-H630	large_intestine	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons