DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_APCC_KENBOX_2

Location: 90:94

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9068

ASA_SCORE: 124.5

COIL: 0.6922

CONS_SCORE: 0.5794

DSS_SCORE: 0.4964

HELIX: 0.3008

FCONS_SCORE: 0.9175

RIG_SCORE: 0.6967

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S88Y	TCGA-06-0939	GBM	TCGA	RKENL	DEG_APCC_KENBOX_2	0.2778
p.S88Y	DO12130	GBM	ICGC	RKENL	DEG_APCC_KENBOX_2	0.2778
p.H99R	TCGA-AA-3681	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1944
p.H99R	DO9682	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.R102I	TCGA-AA-A00N	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1111
p.R102I	DO9876	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1111
p.H104Y	TCGA-F5-6814	READ	TCGA	RKENL	DEG_APCC_KENBOX_2	0.0556
p.H104Y	DO36556	READ	ICGC	RKENL	DEG_APCC_KENBOX_2	0.0556
p.K103R	TCGA-ND-A4WF	UCS	TCGA	RKENL	DEG_APCC_KENBOX_2	0.1944
p.H99N	DO50338	ESAD	ICGC	RKENL	DEG_APCC_KENBOX_2	0.1944
p.P95T	DO229022	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95Q	DO229027	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.N93I	DO222358	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	0.728
p.N93I	SIDM01033	Bladder Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.728
p.N93I	KU-19-19	urinary_tract	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.728
p.P95L	SIDM00845	Burkitt's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM00967	Ovarian Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM01039	Other Solid Cancers	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM00807	Bladder Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM00793	Burkitt's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM01664	Prostate Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.P95L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.3056
p.E92Q	SIDM00938	Breast Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.6744
p.E92Q	ACH-000902	Breast Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.6744
p.E92Q	CAL-148	breast	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.6744
p.E87Q	SIDM00630	Breast Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.25
p.E87Q	ACH-000876	Breast Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.25
p.E87Q	MDA-MB-415	breast	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.25
p.Q83E	SIDM00590	Oral Cavity Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	0.1389
p.Q83E	ACH-000472	Head and Neck Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.1389
p.Q83E	HSC-2	upper_aerodigestive_tract	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.1389
p.R90K	SIDM00006	Other Solid Cancers	GDSC	RKENL	DEG_APCC_KENBOX_2	0.6126
p.R90K	ACH-001552	Skin Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	0.6126
p.R90K	MCC26	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	0.6126
p.Y86C	ACH-001484	Leukemia	CCLE	RKENL	DEG_APCC_KENBOX_2	0.6667
p.Y86C	ACH-001485	Leukemia	CCLE	RKENL	DEG_APCC_KENBOX_2	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_APCC_KENBOX_2	90:94	RKENL	APC,CDC20,FZR1	0.9068	More...
Q9UBU7	Protein DBF4 homolog A	DEG_APCC_KENBOX_2	586:590	RKENL	APC,CDC20,FZR1	0.6044	More...
O00515	Ladinin-1	DEG_APCC_KENBOX_2	461:465	RKENL	APC,CDC20,FZR1	0.9951	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RKENL

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of RKENL