DegronMD - P20930(FLG)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G2349R	TCGA-02-2466	GBM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.1111
p.G2349R	DO13480	GBM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.1111
p.G2349R	SIDM01128	Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.1111
p.D2460E	TCGA-05-4403	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.D2460E	DO23631	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.T748S	TCGA-05-4424	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	DO229057	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	DO229059	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	DO229061	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	DO23672	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	SIDM00150	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.T748S	KM12	large intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1667
p.G3948C	TCGA-06-0213	GBM	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.2778
p.G3948C	TCGA-17-Z015	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.2778
p.G3948C	DO11836	GBM	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.2778
p.S88Y	TCGA-06-0939	GBM	TCGA	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.2778
p.S88Y	DO12130	GBM	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.2778
p.R1699H	TCGA-14-0817	GBM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	TCGA-14-0817	GBM	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	TCGA-V5-A7RE	ESCA	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	TCGA-V5-A7RE	ESCA	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	DO234459	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	DO234459	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	DO13653	GBM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	DO13653	GBM	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	SIDM00136	Colorectal Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	SIDM00136	Colorectal Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	SIDM01121	Small Cell Lung Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	SIDM01121	Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	ACH-000358	Lung Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	ACH-000358	Lung Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	ACH-000552	Colon/Colorectal Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	ACH-000552	Colon/Colorectal Cancer	CCLE	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	HT-29	large intestine	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	HT-29	large intestine	COSMIC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699H	NCI-H69	lung	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699H	NCI-H69	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R3270L	TCGA-17-Z031	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.S1683F	TCGA-18-3415	LUSC	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.S1683F	DO26427	LUSC	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.S365Y	TCGA-19-5956	GBM	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.712
p.S365Y	DO13863	GBM	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.712
p.G2373E	TCGA-21-1079	LUSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.0556
p.G2373E	DO26846	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.0556
p.R1712Q	TCGA-21-1079	LUSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation altering degron motif	0.6218
p.R1712Q	DO26846	LUSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation altering degron motif	0.6218
p.S1704Y	TCGA-2Y-A9H3	LIHC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.S1704Y	DO219525	LIHC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.F1441L	TCGA-34-8454	LUSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.587
p.F1441L	DO50094	LUSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.587
p.F1441L	DO35575	PBCA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.587
p.R366S	TCGA-34-8455	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366S	DO50095	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.G1400R	TCGA-3N-A9WC	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0556
p.G1400R	DO51234	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0556
p.E116K	TCGA-3N-A9WD	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	TCGA-EE-A3AA	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	TCGA-GN-A268	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	DO222632	MELA	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	DO37571	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	DO37477	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.E116K	DO51235	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.R366H	TCGA-49-AAR4	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	TCGA-AA-3864	COAD	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	TCGA-UY-A78O	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	DO219035	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	DO8490	COAD	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	DO218920	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	ACH-001669	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.R366H	ACH-002238	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.Q1004K	TCGA-55-7995	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1667
p.Q1004K	DO45323	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1667
p.A1689V	TCGA-55-8507	LUAD	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.5825
p.A1689V	DO45412	LUAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.5825
p.G738R	TCGA-57-1992	OV	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7568
p.G738R	DO32247	OV	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7568
p.Q729K	TCGA-63-A5MW	LUSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1389
p.Q729K	DO219169	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1389
p.Q2367H	TCGA-64-5779	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.2222
p.Q2367H	DO24930	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.2222
p.R740L	TCGA-67-3771	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7316
p.R740L	DO25797	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.7316
p.H1063Q	TCGA-75-5126	LUAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.647
p.H1063Q	DO23711	LUAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.647
p.A361G	TCGA-77-8128	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.754
p.A361G	DO26464	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.754
p.Q1718K	TCGA-77-A5G6	LUSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.Q1718K	DO50097	LUSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.H3278Y	TCGA-86-8278	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.3056
p.H3278Y	DO26308	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.3056
p.R2473S	TCGA-86-8358	LUAD	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.R2473S	DO25471	LUAD	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.R3947C	TCGA-95-A4VN	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947C	TCGA-AP-A1DK	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947C	DO51199	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947C	DO42033	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947C	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.G2475A	TCGA-A3-3320	KIRC	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1944
p.G2475A	TCGA-G2-A3VY	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1944
p.G2475A	DO590	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1944
p.A3288E	TCGA-A5-A0G2	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.1944
p.A3288E	DO41235	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.1944
p.P2466L	TCGA-A5-A1OF	UCEC	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7582
p.P2466L	DO32819	PACA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7582
p.P2466L	DO42568	UCEC	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7582
p.P2466L	SIDM01136	Pancreatic Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7582
p.P2466L	PANC-08-13	pancreas	COSMIC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7582
p.S3283F	TCGA-A8-A07G	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.9093
p.S3283F	DO2870	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.9093
p.G1386E	TCGA-A8-A08G	BRCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.7199
p.G1386E	DO3763	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.7199
p.H99R	TCGA-AA-3681	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.H99R	DO9682	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.R102I	TCGA-AA-A00N	COAD	TCGA	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.R102I	DO9876	COAD	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1111
p.S3659T	TCGA-AP-A051	UCEC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.6005
p.S3659T	DO42673	UCEC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.6005
p.R1428C	TCGA-AP-A0LM	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.R1428C	TCGA-BR-4362	STAD	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.R1428C	DO38336	STAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.R1428C	DO43306	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.R1428C	SIDM01635	Glioblastoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.Q3945R	TCGA-AP-A1DK	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1944
p.Q3945R	DO42033	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1944
p.L1442I	TCGA-AP-A1DV	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.7174
p.L1442I	DO43186	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.7174
p.H1681Y	TCGA-AR-A1AJ	BRCA	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.H1681Y	DO4062	BRCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.Q2474E	TCGA-AR-A24Q	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2222
p.Q2474E	DO3524	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2222
p.G2458C	TCGA-AR-A24V	BRCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1111
p.G2458C	DO2848	BRCA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1111
p.D1690G	TCGA-B5-A0K9	UCEC	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.6087
p.D1690G	DO42097	UCEC	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.6087
p.E129D	TCGA-B5-A121	UCEC	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.E129D	DO43394	UCEC	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.H2360Q	TCGA-B8-4148	KIRC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.647
p.H2360Q	DO19168	KIRC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.647
p.S1434R	TCGA-B8-5158	KIRC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.2222
p.S1434R	DO18592	KIRC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.2222
p.E1011Q	TCGA-BA-6869	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.5633
p.E1011Q	DO14250	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.5633
p.H1685N	TCGA-BC-A8YO	LIHC	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.2222
p.H1685N	DO49658	LIHC	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.2222
p.D2460N	TCGA-BF-AAOU	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.D2460N	DO219460	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1667
p.S372F	TCGA-BG-A222	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1389
p.S372F	DO42977	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1389
p.V734F	TCGA-BH-A0B1	BRCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2778
p.V734F	DO4837	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2778
p.R3277C	TCGA-BR-4370	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.R3277C	TCGA-CG-5730	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.R3277C	DO38499	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.R3277C	DO38324	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.W1064R	TCGA-BR-6802	STAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7523
p.W1064R	TCGA-WS-AB45	COAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7523
p.W1064R	DO51734	COAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7523
p.W1064R	DO228967	LICA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7523
p.W1064R	DO38332	STAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7523
p.S1398R	TCGA-BR-A4QL	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.S1398R	DO38723	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.S1447Y	TCGA-BS-A0UF	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.S1447Y	DO41488	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.E2479A	TCGA-BT-A42C	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.0833
p.E2479A	DO49725	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.0833
p.A1010P	TCGA-C8-A134	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.6392
p.A1010P	DO1316	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.6392
p.S743G	TCGA-CD-A4MG	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.3056
p.S743G	DO48009	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.3056
p.K109E	TCGA-CF-A1HS	BLCA	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation substituting flanking lysine	0.1944
p.K109E	DO486	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation substituting flanking lysine	0.1944
p.A3279T	TCGA-CG-4469	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.7139
p.A3279T	TCGA-E6-A1LZ	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.7139
p.A3279T	DO228960	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.7139
p.A3279T	DO38507	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.7139
p.A3279T	DO41398	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.7139
p.A1019V	TCGA-CH-5765	PRAD	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.A1019V	TCGA-RD-A8NB	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.A1019V	DO36311	PRAD	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.A1019V	DO50142	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.A1019V	SIDM00889	Cervical Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.A1019V	C-33-A	cervix	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.1944
p.E2479D	TCGA-CK-4948	COAD	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.0833
p.E2479D	DO10598	COAD	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.0833
p.R1437H	TCGA-CM-5862	COAD	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.R1437H	DO7807	COAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.R130T	TCGA-CN-4723	HNSC	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1111
p.R130T	DO14830	HNSC	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1111
p.A1689P	TCGA-CN-6989	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.6392
p.A1689P	DO14814	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation altering degron motif	0.6392
p.R740Q	TCGA-CR-6473	HNSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6218
p.R740Q	DO14228	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6218
p.R3270H	TCGA-CR-7371	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270H	TCGA-DD-A4NH	LIHC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270H	DO15454	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270H	DO44907	LIHC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.S1440P	TCGA-CR-7371	HNSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.5641
p.S1440P	DO15454	HNSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.5641
p.Q1701K	TCGA-CR-7389	HNSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1389
p.Q1701K	TCGA-CR-7389	HNSC	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.Q1701K	DO14190	HNSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1389
p.Q1701K	DO14190	HNSC	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.S2470R	TCGA-CV-6938	HNSC	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7427
p.S2470R	DO14462	HNSC	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.7427
p.R122K	TCGA-D3-A8GC	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6126
p.R122K	TCGA-GN-A4U5	SKCM	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6126
p.R122K	DO50281	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6126
p.R122K	DO51257	SKCM	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6126
p.S1014F	TCGA-D3-A8GQ	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.9093
p.S1014F	DO51246	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.9093
p.R1388L	TCGA-D6-A74Q	HNSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.7316
p.R1388L	DO52087	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.7316
p.S127G	TCGA-D7-A6F0	STAD	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation blocking phosphorylation signal	0.6389
p.S127G	DO50120	STAD	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation blocking phosphorylation signal	0.6389
p.E1452Q	TCGA-D8-A1JC	BRCA	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1667
p.E1452Q	DO6056	BRCA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1667
p.G1065R	TCGA-D9-A3Z1	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.6457
p.G1065R	DO38105	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.6457
p.G2349E	TCGA-D9-A6EC	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.1111
p.G2349E	DO50291	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.1111
p.G3645R	TCGA-DA-A95Z	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.1111
p.G3645R	DO219481	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.1111
p.G3645R	ACH-000938	Leukemia	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.1111
p.G3645R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.1111
p.R740G	TCGA-DD-AAC8	LIHC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6457
p.R740G	DO52193	LIHC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.6457
p.S3271C	TCGA-DG-A2KM	CESC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.1111
p.S3271C	DO51597	CESC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.1111
p.Q2459E	TCGA-DK-A2I4	BLCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.Q2459E	DO465	BLCA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.E1023K	TCGA-DK-AA71	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.0833
p.E1023K	DO219010	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.0833
p.R1700T	TCGA-DM-A1D0	COAD	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1111
p.R1700T	TCGA-DM-A1D0	COAD	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1389
p.R1700T	DO10260	COAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1111
p.R1700T	DO10260	COAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1389
p.S1440A	TCGA-E1-A7YW	LGG	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.6477
p.S1440A	DO219803	LGG	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.6477
p.H3941N	TCGA-E6-A1LX	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.H3941N	DO41020	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.G2471R	TCGA-EB-A3XD	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.G2471R	DO37871	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.G2471R	ACH-001172	Brain Cancer	CCLE	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.3056
p.E1433K	TCGA-EB-A4XL	SKCM	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1944
p.E1433K	DO47401	SKCM	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1944
p.G3655E	TCGA-EB-A551	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.7199
p.G3655E	DO47453	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.7199
p.G3655R	TCGA-EB-A551	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.7568
p.G3655R	DO47453	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation altering degron motif	0.7568
p.G2464E	TCGA-EE-A29D	SKCM	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2778
p.G2464E	DO38123	SKCM	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2778
p.G3285E	TCGA-EE-A2MM	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.G3285E	DO222678	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.G3285E	DO37770	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.G2359R	TCGA-EE-A2MR	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.7568
p.G2359R	DO37819	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.7568
p.R1051C	TCGA-EO-A22R	UCEC	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	DO222371	BTCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	DO227976	COCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	DO233765	GACA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	DO42713	UCEC	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	SIDM00145	T-Lymphoblastic Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.R1051C	ACH-001127	Leukemia	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.0833
p.G1432E	TCGA-ER-A19G	SKCM	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1667
p.G1432E	DO47284	SKCM	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1667
p.D1073N	TCGA-ER-A42K	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1389
p.D1073N	DO51252	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1389
p.R359C	TCGA-EY-A1GI	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.R359C	TCGA-FI-A2D5	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.R359C	DO41211	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.R359C	DO41331	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.H104Y	TCGA-F5-6814	READ	TCGA	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.H104Y	DO36556	READ	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.0556
p.Q3293E	TCGA-F5-6863	READ	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0556
p.Q3293E	DO37042	READ	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0556
p.S1704C	TCGA-FD-A3SP	BLCA	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.S1704C	DO594	BLCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.H1009D	TCGA-FF-8042	DLBC	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.H1009D	DO222306	DLBC	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.S1055L	TCGA-FR-A728	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation blocking phosphorylation signal	0.6389
p.S1055L	DO48550	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation blocking phosphorylation signal	0.6389
p.S1001N	TCGA-FS-A1ZA	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.0833
p.S1001N	DO37551	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.0833
p.P1008L	TCGA-FS-A4F0	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.2778
p.P1008L	DO37891	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.2778
p.G3943E	TCGA-FW-A3R5	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1389
p.G3943E	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1389
p.E1723K	TCGA-FW-A3R5	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.E1723K	DO37406	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.H3957R	TCGA-G4-6309	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.H3957R	DO7810	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R124I	TCGA-GS-A9TZ	DLBC	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.R124I	DO219918	DLBC	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.R124I	DO51955	PRAD	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2778
p.S1020A	TCGA-H7-A6C4	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	DO49995	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	ACH-000598	Myeloma	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	ACH-000697	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	ACH-000758	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	ACH-000990	Endometrial/Uterine Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	ACH-002161	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	MKN28	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.S1020A	A3-KAW	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.6111
p.A1378G	TCGA-HT-A616	LGG	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1667
p.A1378G	DO48605	LGG	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1667
p.I3944M	TCGA-IN-A7NU	STAD	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1667
p.I3944M	DO51746	STAD	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1667
p.A1057E	TCGA-L5-A8NG	ESCA	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.25
p.S2476Y	TCGA-L5-A8NT	ESCA	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation blocking phosphorylation signal	0.6111
p.S2476Y	DO229045	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation blocking phosphorylation signal	0.6111
p.G3284R	TCGA-MP-A4TF	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.3056
p.G3284R	DO45316	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.3056
p.H3957N	TCGA-ND-A4WC	UCS	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.K103R	TCGA-ND-A4WF	UCS	TCGA	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation substituting flanking lysine	0.1944
p.G1432V	TCGA-OR-A5KB	ACC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1667
p.E3668K	TCGA-PQ-A6FN	BLCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.0833
p.E3668K	DO48579	BLCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.0833
p.S1703L	TCGA-QB-A6FS	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation blocking phosphorylation signal	0.6389
p.S1703L	TCGA-QB-A6FS	SKCM	TCGA	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation blocking phosphorylation signal	0.5
p.S1703L	DO48654	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation blocking phosphorylation signal	0.6389
p.S1703L	DO48654	SKCM	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation blocking phosphorylation signal	0.5
p.S1056F	TCGA-QB-A6FS	SKCM	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.2222
p.S1056F	DO48654	SKCM	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.2222
p.A3279G	TCGA-RD-A8N6	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.754
p.A3279G	DO50140	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.754
p.A1381S	TCGA-SL-A6JA	UCEC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.25
p.A1381S	DO219787	UCEC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.25
p.E111K	TCGA-UY-A9PF	BLCA	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.E111K	DO219044	BLCA	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.G1374V	TCGA-VQ-A8P5	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0556
p.G1374V	DO51763	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0556
p.G1062R	TCGA-VQ-A8P8	STAD	TCGA	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7568
p.G1062R	DO51764	STAD	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7568
p.G1062R	ACH-002664	Colon/Colorectal Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7568
p.R1388Q	TCGA-VQ-A8PC	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6218
p.R1388Q	DO217844	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6218
p.R1388Q	DO51767	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6218
p.G367A	TCGA-VQ-A8PD	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.G367A	DO51768	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.G2464R	TCGA-VQ-A8PY	STAD	TCGA	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2778
p.G2464R	DO50879	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2778
p.G2464R	DO51779	STAD	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.2778
p.R1383K	TCGA-VS-A8EK	CESC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.3056
p.R1383K	DO51623	CESC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.3056
p.H3951D	TCGA-VS-A958	CESC	TCGA	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation altering degron motif	0.6577
p.H3951D	DO51639	CESC	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation altering degron motif	0.6577
p.E120K	TCGA-VS-A9UL	CESC	TCGA	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.7022
p.E120K	DO51643	CESC	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.7022
p.E120K	DO222710	MELA	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.7022
p.G1724R	TCGA-W3-A825	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0556
p.G1724R	DO51272	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0556
p.E3280K	TCGA-ZJ-AAXD	CESC	TCGA	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.591
p.E3280K	DO219754	CESC	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.591
p.E3280K	SIDM00630	Breast Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.591
p.E3280K	ACH-000876	Breast Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.591
p.R2356S	DO48451	BLCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.3056
p.T1007S	DO872	BOCA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.25
p.A361T	DO222501	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	DO225404	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	DO228950	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00588	Oral Cavity Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00570	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00425	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM01034	B-Lymphoblastic Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00437	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00465	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM00397	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM01660	Kidney Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM01444	Glioblastoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM01469	Pancreatic Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	SIDM01662	Plasma Cell Myeloma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	HSC-4	upper aerodigestive tract	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	MOLM-13	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	OVTOKO	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	Set2	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	NUGC-4	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.A361T	OVMIU	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation altering degron motif	0.7139
p.S3662T	DO222785	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO228494	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO228712	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO228740	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO50988	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO224558	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO224610	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO52363	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.S3662T	DO52365	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.25
p.A1054S	DO52488	COCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1667
p.R1376G	DO229010	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.R1376G	DO229016	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.R1376G	DO229003	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.R1376G	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.R1376G	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1111
p.R1684H	DO229010	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.R1684H	DO229016	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.R1684H	DO229003	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.R1684H	DO229489	LAML	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.R1684H	DO228941	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.R1699C	DO229010	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO229010	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699C	DO229016	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO229016	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699C	DO229003	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO229003	COCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699C	DO234150	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO234150	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699C	DO229489	LAML	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO229489	LAML	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.R1699C	DO228941	LICA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.0833
p.R1699C	DO228941	LICA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1667
p.H99N	DO50338	ESAD	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1944
p.A2354V	DO50307	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.R1684C	DO234204	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1944
p.G1429R	DO234235	ESAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0833
p.G728R	DO234263	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.G728R	DO234362	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.G728R	DO234417	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.G728R	SIDM01090	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.G1707R	DO234179	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.3056
p.G1707R	SIDM00124	Kidney Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.3056
p.G1707R	ACH-000555	Kidney Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.3056
p.G1707R	A498	kidney	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.3056
p.G1374A	DO234401	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0556
p.G1696V	DO234426	ESAD	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.25
p.G1015V	DO233274	GACA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.H727N	DO15591	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0833
p.V1395A	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1944
p.V1395A	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1944
p.T1396S	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1667
p.N1397D	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1389
p.N1397D	SIDM01090	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1389
p.N1397D	SIDM00210	Ovarian Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1389
p.N1397D	SIDM00863	Burkitt's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1389
p.S2366T	DO224778	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO51036	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO51037	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO51002	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO229028	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.S2366T	DO52338	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25
p.P1008R	DO228945	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.2778
p.S1390Y	DO228945	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.712
p.S1390Y	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.712
p.S1390Y	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.712
p.S1390Y	SIDM00479	Esophageal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.712
p.S750N	DO228945	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.S750N	DO228950	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.S750N	DO229057	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.S750N	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.1111
p.R1439G	DO228944	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.7568
p.R1439G	DO229030	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation altering degron motif	0.7568
p.R3270S	DO228950	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270S	DO229052	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270S	DO229051	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270S	AN3-CA	endometrium	COSMIC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.R3270S	SK-MEL-2	skin	COSMIC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0833
p.H2463R	DO228950	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.H2463R	DO220911	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.25
p.S1066T	DO228848	LICA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.6005
p.E3280Q	DO228960	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.5633
p.A370E	DO229018	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1944
p.P95T	DO229022	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.H2477N	DO229024	LICA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.H2477N	SIDM00255	Neuroblastoma	GDSC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.H2477N	ACH-002282	Neuroblastoma	CCLE	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.H2477N	NB17	autonomic ganglia	COSMIC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation rewiring degron network	0.1389
p.P95Q	DO229027	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.Q3293K	DO229026	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.0556
p.S2363Y	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.712
p.S2363Y	DO229056	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation altering degron motif	0.712
p.T3281N	DO229036	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation altering degron motif	0.8166
p.A1010E	DO229045	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.7701
p.S1447T	DO229052	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.T369A	DO229052	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.T369A	DO229056	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.T369A	DO229055	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.S742Y	DO229055	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.712
p.S742Y	DO229208	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.712
p.S742Y	DO229250	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation altering degron motif	0.712
p.T358N	DO229063	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.25
p.N93I	DO222358	LICA	ICGC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.728
p.N93I	SIDM01033	Bladder Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.728
p.N93I	KU-19-19	urinary tract	COSMIC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.728
p.S127N	DO45096	LIRI	ICGC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation blocking phosphorylation signal	0.6389
p.E3961Q	DO229101	LMS	ICGC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.1389
p.A3664D	DO231179	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.1944
p.S1453A	DO52650	MALY	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.1389
p.S1056C	DO220864	MELA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.2222
p.S372Y	DO220864	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.1389
p.S352R	DO220864	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation blocking phosphorylation signal	0.5278
p.S1704F	DO220891	MELA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.2222
p.G1456E	DO222363	MELA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.G2467R	DO222542	MELA	ICGC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.6457
p.S732F	DO222743	MELA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.2222
p.G1707A	DO46356	OV	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.3056
p.S1066F	DO232224	PBCA	ICGC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7982
p.G367E	DO229494	SKCA	ICGC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2778
p.G3669E	DO218849	SKCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.0556
p.D1694H	DO231475	THCA	ICGC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.3056
p.T3276S	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.25
p.T3276S	ACH-000365	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.25
p.T3276S	SU-DHL-4	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.25
p.R1052G	SIDM00353	Other Sarcomas	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00614	Hepatocellular Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM01040	Ovarian Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00569	Osteosarcoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00057	Neuroblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00552	Rhabdomyosarcoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00457	Plasma Cell Myeloma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM01196	Hepatocellular Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00346	Chronic Myelogenous Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM01210	Glioblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00543	Melanoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00363	Acute Myeloid Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00026	Other Solid Cancers	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM01727	Chronic Myelogenous Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00170	Head and Neck Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM01694	B-Lymphoblastic Leukemia	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R1052G	SIDM00162	Biliary Tract Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1111
p.R3947L	SIDM01119	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947L	ACH-000775	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.R3947L	NCI-H727	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.25
p.G1062E	SIDM00545	Melanoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7199
p.G1062E	SIDM01412	Oral Cavity Carcinoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7199
p.G1062E	ACH-000762	Head and Neck Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7199
p.G1062E	ACH-000987	Skin Cancer	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7199
p.G1062E	Mewo	skin	COSMIC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation altering degron motif	0.7199
p.R1428H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.R1428H	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0556
p.P95L	SIDM00845	Burkitt's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM00967	Ovarian Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM01039	Other Solid Cancers	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM00807	Bladder Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM00793	Burkitt's Lymphoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM01664	Prostate Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.P95L	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.3056
p.H3941R	SIDM01090	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.H3941R	SIDM00210	Ovarian Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.H3941R	SIDM00863	Burkitt's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.D1708N	SIDM01090	Colorectal Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation altering degron motif	0.6932
p.D1708N	SIDM00210	Ovarian Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation altering degron motif	0.6932
p.D1708N	SIDM00863	Burkitt's Lymphoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation altering degron motif	0.6932
p.R1437L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.R1437L	ACH-000665	Lung Cancer	CCLE	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.R1437L	SK-MES-1	lung	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.Q1701E	SIDM00258	Neuroblastoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1389
p.Q1701E	SIDM00258	Neuroblastoma	GDSC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.Q1701E	NB12	autonomic ganglia	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	1708:1714	Mutation rewiring degron network	0.1389
p.Q1701E	NB12	autonomic ganglia	COSMIC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.1111
p.E92Q	SIDM00938	Breast Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6744
p.E92Q	ACH-000902	Breast Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6744
p.E92Q	CAL-148	breast	COSMIC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6744
p.G726R	SIDM00393	Gastric Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.0556
p.H1387Y	SIDM01126	Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6118
p.H1387Y	SIDM00846	Cervical Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6118
p.H1387Y	SIDM00844	Burkitt's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation altering degron motif	0.6118
p.D351E	SIDM00120	Prostate Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.D351E	ACH-000979	Prostate Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.D351E	DU-145	prostate	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.A1071V	SIDM00157	Neuroblastoma	GDSC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1944
p.A1071V	ACH-002261	Neuroblastoma	CCLE	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1944
p.A1071V	KP-N-YS	autonomic ganglia	COSMIC	DSGHWGS	DEG_SCF_TRCP1_1	1060:1066	Mutation rewiring degron network	0.1944
p.G1429S	SIDM00623	Other Blood Cancers	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0833
p.G1429S	ACH-002339	Leukemia	CCLE	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0833
p.G1429S	Mo-T	haematopoietic and lymphoid tissue	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.0833
p.E87Q	SIDM00630	Breast Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.25
p.E87Q	ACH-000876	Breast Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.25
p.E87Q	MDA-MB-415	breast	COSMIC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.25
p.G2467E	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.6087
p.G2467E	KYSE-410	oesophagus	COSMIC	PGSSS	DEG_SPOP_SBC_1	2466:2470	Mutation altering degron motif	0.6087
p.Q83E	SIDM00590	Oral Cavity Carcinoma	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.Q83E	ACH-000472	Head and Neck Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.Q83E	HSC-2	upper aerodigestive tract	COSMIC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation rewiring degron network	0.1389
p.E374K	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.E374K	ACH-000447	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.E374K	NCI-H2228	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0833
p.G1696D	SIDM00350	Head and Neck Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.25
p.G1696D	SAT	upper aerodigestive tract	COSMIC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.25
p.S745R	SIDM00282	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.25
p.S745R	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.25
p.S745R	CW-2	large intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	736:742	Mutation rewiring degron network	0.25
p.R1437S	SIDM00879	Breast Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.R1437S	HCC1500	breast	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	1438:1446	Mutation rewiring degron network	0.3056
p.E1399D	SIDM01045	Endometrial Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.E1399D	ACH-000978	Endometrial/Uterine Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.E1399D	EN	endometrium	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.H1009R	SIDM01045	Endometrial Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.H1009R	ACH-000978	Endometrial/Uterine Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.H1009R	EN	endometrium	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation rewiring degron network	0.3056
p.S1013F	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.9093
p.S1013F	ACH-000945	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.9093
p.S1013F	NCI-H650	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation altering degron motif	0.9093
p.V1395I	SIDM00280	Gastric Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1944
p.V1395I	ACH-000560	Gastric Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1944
p.V1395I	ECC10	stomach	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.1944
p.R90K	SIDM00006	Other Solid Cancers	GDSC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6126
p.R90K	ACH-001552	Skin Cancer	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6126
p.R90K	MCC26	skin	COSMIC	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation altering degron motif	0.6126
p.T3963N	SIDM00882	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.T3963N	ACH-002089	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.T3963N	201T	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.T3963N	HCC1419	breast	COSMIC	PHSSS	DEG_SPOP_SBC_1	3950:3954	Mutation rewiring degron network	0.0833
p.H360Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.H360Q	ACH-000916	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.H360Q	NCI-H1573	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.3056
p.H1375Y	SIDM00217	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.H1375Y	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.H1375Y	SNU-1040	large intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	1384:1390	Mutation rewiring degron network	0.0833
p.Q1686R	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.25
p.Q1686R	PC-3_[JPC-3]	lung	COSMIC	ADSST	DEG_SPOP_SBC_1	1689:1693	Mutation rewiring degron network	0.25
p.T369N	SIDM01318	Hepatocellular Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.T369N	ACH-001318	Liver Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.2222
p.R3277L	SIDM01526	Mesothelioma	GDSC	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.R3277L	ACH-000086	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	3279:3283	Mutation rewiring degron network	0.2778
p.Q375L	ACH-000087	Bone Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	361:365	Mutation rewiring degron network	0.0556
p.E3668D	ACH-000238	Head and Neck Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.0833
p.S3660R	ACH-000560	Gastric Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	3653:3659	Mutation rewiring degron network	0.3056
p.Y86C	ACH-001484	Leukemia	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation blocking phosphorylation signal	0.6667
p.Y86C	ACH-001485	Leukemia	CCLE	RKENL	DEG_APCC_KENBOX_2	90:94	Mutation blocking phosphorylation signal	0.6667
p.S2364R	ECC10	stomach	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.3056
p.S127R	FTC-133	thyroid	COSMIC	NKENR	DEG_APCC_KENBOX_2	118:122	Mutation blocking phosphorylation signal	0.6389
p.S1021P	H513	pleura	COSMIC	AETSS	DEG_SPOP_SBC_1	1010:1014	Mutation blocking phosphorylation signal	0.5833
p.A2354T	K-562	haematopoietic and lymphoid tissue	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	2357:2363	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FLG

UniProt ID: P20930

Entrez ID: 2312

Protein name: Filaggrin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FLG in