DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_APCC_DBOX_1

Location: 1438:1446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5416

ASA_SCORE: 115.6667

COIL: 0.8734

CONS_SCORE: 0.2857

DSS_SCORE: 0.7211

HELIX: 0.0819

FCONS_SCORE: 0.7207

RIG_SCORE: 0.6445

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1439G	DO228944	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7568
p.R1439G	DO229030	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7568
p.L1442I	TCGA-AP-A1DV	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.7174
p.L1442I	DO43186	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7174
p.S1440A	TCGA-E1-A7YW	LGG	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.6477
p.S1440A	DO219803	LGG	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.6477
p.F1441L	TCGA-34-8454	LUSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.F1441L	DO50094	LUSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.F1441L	DO35575	PBCA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.S1440P	TCGA-CR-7371	HNSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.5641
p.S1440P	DO15454	HNSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.5641
p.S1447Y	TCGA-BS-A0UF	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1447Y	DO41488	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437H	TCGA-CM-5862	COAD	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437H	DO7807	COAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1447T	DO229052	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437L	ACH-000665	Lung Cancer	CCLE	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437L	SK-MES-1	lung	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437S	SIDM00879	Breast Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437S	HCC1500	breast	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1434R	TCGA-B8-5158	KIRC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.2222
p.S1434R	DO18592	KIRC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.2222
p.E1433K	TCGA-EB-A4XL	SKCM	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.1944
p.E1433K	DO47401	SKCM	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.1944

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Drug responses associated with FLG mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of SRSFLYQVS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_APCC_DBOX_1	1438:1446	SRSFLYQVS	APC,CDC20,FZR1	0.5416	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSFLYQVS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of SRSFLYQVS