DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_APCC_DBOX_1

Location: 1438:1446

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5416

ASA_SCORE: 115.6667

COIL: 0.8734

CONS_SCORE: 0.2857

DSS_SCORE: 0.7211

HELIX: 0.0819

FCONS_SCORE: 0.7207

RIG_SCORE: 0.6445

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F1441L	TCGA-34-8454	LUSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.F1441L	DO50094	LUSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.F1441L	DO35575	PBCA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.587
p.R1428C	TCGA-AP-A0LM	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428C	TCGA-BR-4362	STAD	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428C	DO38336	STAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428C	DO43306	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428C	SIDM01635	Glioblastoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.L1442I	TCGA-AP-A1DV	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.7174
p.L1442I	DO43186	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7174
p.S1434R	TCGA-B8-5158	KIRC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.2222
p.S1434R	DO18592	KIRC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.2222
p.S1447Y	TCGA-BS-A0UF	UCEC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1447Y	DO41488	UCEC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437H	TCGA-CM-5862	COAD	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437H	DO7807	COAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1440P	TCGA-CR-7371	HNSC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.5641
p.S1440P	DO15454	HNSC	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.5641
p.E1452Q	TCGA-D8-A1JC	BRCA	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.1667
p.E1452Q	DO6056	BRCA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.1667
p.S1440A	TCGA-E1-A7YW	LGG	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.6477
p.S1440A	DO219803	LGG	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.6477
p.E1433K	TCGA-EB-A4XL	SKCM	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.1944
p.E1433K	DO47401	SKCM	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.1944
p.G1432E	TCGA-ER-A19G	SKCM	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.1667
p.G1432E	DO47284	SKCM	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.1667
p.G1432V	TCGA-OR-A5KB	ACC	TCGA	SRSFLYQVS	DEG_APCC_DBOX_1	0.1667
p.G1429R	DO234235	ESAD	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0833
p.R1439G	DO228944	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7568
p.R1439G	DO229030	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.7568
p.S1447T	DO229052	LICA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.S1453A	DO52650	MALY	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.1389
p.G1456E	DO222363	MELA	ICGC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428H	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1428H	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0556
p.R1437L	SIDM01103	Squamous Cell Lung Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437L	ACH-000665	Lung Cancer	CCLE	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437L	SK-MES-1	lung	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.G1429S	SIDM00623	Other Blood Cancers	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0833
p.G1429S	ACH-002339	Leukemia	CCLE	SRSFLYQVS	DEG_APCC_DBOX_1	0.0833
p.G1429S	Mo-T	haematopoietic_and_lymphoid_tissue	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.0833
p.R1437S	SIDM00879	Breast Carcinoma	GDSC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056
p.R1437S	HCC1500	breast	COSMIC	SRSFLYQVS	DEG_APCC_DBOX_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSFLYQVS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of SRSFLYQVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_APCC_DBOX_1	1438:1446	SRSFLYQVS	APC,CDC20,FZR1	0.5416	More...