DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 1708:1714

E3 ligase: BTRC

DEGRON score: 0.9962

ASA_SCORE: 100.5286

COIL: 0.9629

CONS_SCORE: 0.4975

DSS_SCORE: 0.807

HELIX: 0.0206

FCONS_SCORE: 1.137

RIG_SCORE: 0.4964

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1699H	TCGA-14-0817	GBM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	TCGA-V5-A7RE	ESCA	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	DO234459	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	DO13653	GBM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	SIDM00136	Colorectal Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	SIDM01121	Small Cell Lung Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	ACH-000358	Lung Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	ACH-000552	Colon/Colorectal Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	HT-29	large_intestine	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699H	NCI-H69	lung	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1712Q	TCGA-21-1079	LUSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.6218
p.R1712Q	DO26846	LUSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.6218
p.S1704Y	TCGA-2Y-A9H3	LIHC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.S1704Y	DO219525	LIHC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.Q1718K	TCGA-77-A5G6	LUSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.Q1718K	DO50097	LUSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.Q1701K	TCGA-CR-7389	HNSC	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.1389
p.Q1701K	DO14190	HNSC	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.1389
p.R1700T	TCGA-DM-A1D0	COAD	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.1111
p.R1700T	DO10260	COAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.1111
p.S1704C	TCGA-FD-A3SP	BLCA	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.S1704C	DO594	BLCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.E1723K	TCGA-FW-A3R5	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.E1723K	DO37406	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.S1703L	TCGA-QB-A6FS	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.6389
p.S1703L	DO48654	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.6389
p.G1724R	TCGA-W3-A825	SKCM	TCGA	DSGNRGS	DEG_SCF_TRCP1_1	0.0556
p.G1724R	DO51272	SKCM	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0556
p.R1699C	DO229010	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699C	DO229016	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699C	DO229003	COCA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699C	DO234150	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699C	DO229489	LAML	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.R1699C	DO228941	LICA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.0833
p.G1707R	DO234179	ESAD	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.3056
p.G1707R	SIDM00124	Kidney Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.3056
p.G1707R	ACH-000555	Kidney Cancer	CCLE	DSGNRGS	DEG_SCF_TRCP1_1	0.3056
p.G1707R	A498	kidney	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	0.3056
p.S1704F	DO220891	MELA	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.2222
p.G1707A	DO46356	OV	ICGC	DSGNRGS	DEG_SCF_TRCP1_1	0.3056
p.D1708N	SIDM01090	Colorectal Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.6932
p.D1708N	SIDM00210	Ovarian Carcinoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.6932
p.D1708N	SIDM00863	Burkitt's Lymphoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.6932
p.Q1701E	SIDM00258	Neuroblastoma	GDSC	DSGNRGS	DEG_SCF_TRCP1_1	0.1389
p.Q1701E	NB12	autonomic_ganglia	COSMIC	DSGNRGS	DEG_SCF_TRCP1_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGNRGS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of DSGNRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SCF_TRCP1_1	1708:1714	DSGNRGS	BTRC	0.9962	More...