DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 1010:1014

E3 ligase: SPOP

DEGRON score: 0.7759

ASA_SCORE: 93.64

COIL: 0.9292

CONS_SCORE: 0.2303

DSS_SCORE: 0.8932

HELIX: 0.046

FCONS_SCORE: 0.9467

RIG_SCORE: 0.5142

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q1004K	TCGA-55-7995	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1667
p.Q1004K	DO45323	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1667
p.E1011Q	TCGA-BA-6869	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.5633
p.E1011Q	DO14250	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.5633
p.A1010P	TCGA-C8-A134	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.6392
p.A1010P	DO1316	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.6392
p.A1019V	TCGA-CH-5765	PRAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1019V	TCGA-RD-A8NB	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1019V	DO36311	PRAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1019V	DO50142	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1019V	SIDM00889	Cervical Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1019V	C-33-A	cervix	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1944
p.S1014F	TCGA-D3-A8GQ	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.9093
p.S1014F	DO51246	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.9093
p.E1023K	TCGA-DK-AA71	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.E1023K	DO219010	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.H1009D	TCGA-FF-8042	DLBC	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.H1009D	DO222306	DLBC	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S1001N	TCGA-FS-A1ZA	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.S1001N	DO37551	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.P1008L	TCGA-FS-A4F0	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.P1008L	DO37891	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.S1020A	TCGA-H7-A6C4	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	DO49995	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	ACH-000598	Myeloma	CCLE	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	ACH-000697	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	ACH-000758	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	ACH-000990	Endometrial/Uterine Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	ACH-002161	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	MKN28	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	0.6111
p.S1020A	A3-KAW	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.6111
p.T1007S	DO872	BOCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.25
p.G1015V	DO233274	GACA	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.P1008R	DO228945	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.A1010E	DO229045	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7701
p.H1009R	SIDM01045	Endometrial Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.H1009R	ACH-000978	Endometrial/Uterine Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.H1009R	EN	endometrium	COSMIC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S1013F	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.9093
p.S1013F	ACH-000945	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.9093
p.S1013F	NCI-H650	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.9093
p.S1021P	H513	pleura	COSMIC	AETSS	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of AETSS