DegronMD

Uniprot ID: Q5HY92

Source protein: Fidgetin

Source gene: FIGN

Class: DEG_SPOP_SBC_1

Location: 369:373

E3 ligase: SPOP

DEGRON score: 0.9725

ASA_SCORE: 75.94

COIL: 0.6164

CONS_SCORE: 0.2201

DSS_SCORE: 0.6102

HELIX: 0.3614

FCONS_SCORE: 1.0212

RIG_SCORE: 0.6914

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P378Q	TCGA-09-2044	OV	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.P378Q	DO28923	OV	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.R361L	TCGA-49-AARO	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361L	DO218924	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T379M	TCGA-AX-A1C5	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1667
p.T379M	DO41422	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1667
p.T379M	ACH-000586	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1667
p.T379M	NCI-H1876	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1667
p.K377E	TCGA-AY-4071	COAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3333
p.K377E	DO9146	COAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3333
p.F376C	TCGA-B5-A11E	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.25
p.F376C	DO41644	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.25
p.R361W	TCGA-BK-A6W3	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361W	TCGA-BS-A0UV	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361W	TCGA-DK-A6AW	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361W	DO48566	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361W	DO50076	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.R361W	DO42793	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.L382I	DO229037	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.M383V	DO36556	READ	ICGC	AETSS	DEG_SPOP_SBC_1	0.0556
p.S368N	SIDM00845	Burkitt's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S368N	SIDM00035	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S368N	SIDM01519	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S368N	ACH-000992	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.S368N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.3056
p.S368N	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.3056
p.T359S	SIDM00845	Burkitt's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	SIDM00035	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	SIDM01519	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	ACH-000786	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	ACH-000992	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0556
p.T359S	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0556
p.N363Y	SIDM00282	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1667
p.N363Y	ACH-000998	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1667
p.N363Y	CW-2	large_intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1667
p.L374V	SIDM01188	Pancreatic Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.L374V	ACH-000114	Pancreatic Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.L374V	SU8686	pancreas	COSMIC	AETSS	DEG_SPOP_SBC_1	0.3056
p.P378L	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P378L	ACH-001498	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	0.1944
p.P378L	Farage	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with FIGN mutations

All proteins holding degron of AETSS