DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 361:365

E3 ligase: SPOP

DEGRON score: 0.9876

ASA_SCORE: 99.94

COIL: 0.9368

CONS_SCORE: 0.4266

DSS_SCORE: 0.8664

HELIX: 0.0502

FCONS_SCORE: 0.9831

RIG_SCORE: 0.5507

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A361G	TCGA-77-8128	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.754
p.A361G	DO26464	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.754
p.A361T	DO222501	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	DO225404	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	DO228950	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00588	Oral Cavity Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00570	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00425	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01034	B-Lymphoblastic Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00437	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00465	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00397	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01660	Kidney Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01444	Glioblastoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01469	Pancreatic Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01662	Plasma Cell Myeloma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	HSC-4	upper_aerodigestive_tract	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	OVTOKO	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	NUGC-4	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	OVMIU	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.S365Y	TCGA-19-5956	GBM	TCGA	AETSS	DEG_SPOP_SBC_1	0.712
p.S365Y	DO13863	GBM	ICGC	AETSS	DEG_SPOP_SBC_1	0.712
p.S352R	DO220864	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.5278

Showing 1 to 25 of 63 entries

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Drug responses associated with FLG mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of AETSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of AETSS