DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 361:365

E3 ligase: SPOP

DEGRON score: 0.9876

ASA_SCORE: 99.94

COIL: 0.9368

CONS_SCORE: 0.4266

DSS_SCORE: 0.8664

HELIX: 0.0502

FCONS_SCORE: 0.9831

RIG_SCORE: 0.5507

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S365Y	TCGA-19-5956	GBM	TCGA	AETSS	DEG_SPOP_SBC_1	0.712
p.S365Y	DO13863	GBM	ICGC	AETSS	DEG_SPOP_SBC_1	0.712
p.R366S	TCGA-34-8455	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366S	DO50095	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	TCGA-49-AAR4	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	TCGA-AA-3864	COAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	TCGA-UY-A78O	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	DO219035	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	DO8490	COAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	DO218920	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	SIDM01259	B-Lymphoblastic Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	ACH-001669	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.R366H	ACH-002238	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.A361G	TCGA-77-8128	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.754
p.A361G	DO26464	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.754
p.S372F	TCGA-BG-A222	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1389
p.S372F	DO42977	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1389
p.R359C	TCGA-EY-A1GI	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.R359C	TCGA-FI-A2D5	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.R359C	DO41211	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.R359C	DO41331	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.G367A	TCGA-VQ-A8PD	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.G367A	DO51768	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.A361T	DO222501	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	DO225404	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	DO228950	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00588	Oral Cavity Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00570	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00425	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01034	B-Lymphoblastic Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00437	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00465	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM00397	Acute Myeloid Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01660	Kidney Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01444	Glioblastoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01469	Pancreatic Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	SIDM01662	Plasma Cell Myeloma	GDSC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	HSC-4	upper_aerodigestive_tract	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	OVTOKO	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	Set2	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	NUGC-4	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A361T	OVMIU	ovary	COSMIC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A370E	DO229018	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T369A	DO229052	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T369A	DO229056	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T369A	DO229055	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T358N	DO229063	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.25
p.S372Y	DO220864	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1389
p.S352R	DO220864	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.5278
p.G367E	DO229494	SKCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.D351E	SIDM00120	Prostate Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0556
p.D351E	ACH-000979	Prostate Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.0556
p.D351E	DU-145	prostate	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0556
p.E374K	SIDM00729	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0833
p.E374K	ACH-000447	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.0833
p.E374K	NCI-H2228	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0833
p.H360Q	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.H360Q	ACH-000916	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.H360Q	NCI-H1573	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.3056
p.T369N	SIDM01318	Hepatocellular Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T369N	ACH-001318	Liver Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.2222
p.Q375L	ACH-000087	Bone Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of AETSS