DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
AETSS
Uniprot ID:
Q9P2H0
Source protein:
Centrosomal protein of 126 kDa
Source gene:
CEP126
Class:
DEG_SPOP_SBC_1
Location:
541:545
E3 ligase:
SPOP
DEGRON score:
0.8543
ASA_SCORE:
91.84
COIL:
0.7022
CONS_SCORE:
0.4073
DSS_SCORE:
0.5137
HELIX:
0.2806
FCONS_SCORE:
1.0418
RIG_SCORE:
0.6976
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P531A
SIDM01120
Other Solid Cancers
GDSC
AETSS
DEG_SPOP_SBC_1
0.0556
p.P531A
NCI-H720
lung
COSMIC
AETSS
DEG_SPOP_SBC_1
0.0556
Drug responses associated with CEP126 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AETSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P20930
Filaggrin
DEG_SPOP_SBC_1
361:365
AETSS
SPOP
0.9876
More...
P20930
Filaggrin
DEG_SPOP_SBC_1
1010:1014
AETSS
SPOP
0.7759
More...
P20930
Filaggrin
DEG_SPOP_SBC_1
3279:3283
AETSS
SPOP
0.9508
More...
Q5HY92
Fidgetin
DEG_SPOP_SBC_1
369:373
AETSS
SPOP
0.9725
More...
Q5QJE6
Deoxynucleotidyltransferase terminal-interacting protein 2
DEG_SPOP_SBC_1
186:190
AETSS
SPOP
0.989
More...
Q685J3
Mucin-17
DEG_SPOP_SBC_1
1254:1258
AETSS
SPOP
0.6614
More...
Q8N307
Mucin-20
DEG_SPOP_SBC_1
62:66
AETSS
SPOP
0.8974
More...
Q8WXI7
Mucin-16
DEG_SPOP_SBC_1
10688:10692
AETSS
SPOP
0.9245
More...
Q9P2H0
Centrosomal protein of 126 kDa
DEG_SPOP_SBC_1
541:545
AETSS
SPOP
0.8543
More...
Q9Y4K4
Mitogen-activated protein kinase kinase kinase kinase 5
DEG_SPOP_SBC_1
441:445
AETSS
SPOP
0.9965
More...