DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SPOP_SBC_1

Location: 1254:1258

E3 ligase: SPOP

DEGRON score: 0.6614

ASA_SCORE: 96.22

COIL: 0.9136

CONS_SCORE: 0.5236

DSS_SCORE: 0.6789

HELIX: 0.0142

FCONS_SCORE: 1

RIG_SCORE: 0.6129

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1261A	TCGA-17-Z045	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.25
p.G1265V	TCGA-61-2102	OV	TCGA	AETSS	DEG_SPOP_SBC_1	0.1389
p.G1265V	DO31939	OV	ICGC	AETSS	DEG_SPOP_SBC_1	0.1389
p.A1254S	TCGA-92-8063	LUSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.7588
p.A1254S	DO26941	LUSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.7588
p.S1258F	TCGA-EB-A5UL	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.7982
p.S1258F	DO222662	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7982
p.S1258F	DO47601	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.7982
p.E1255K	TCGA-EE-A29B	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.591
p.E1255K	DO47255	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.591
p.T1252P	TCGA-EE-A2GP	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.T1252P	DO37422	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.T1252P	ACH-000945	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.2778
p.T1252P	NCI-H650	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.2778
p.A1263V	TCGA-EJ-7218	PRAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.A1263V	DO51310	PRAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249L	TCGA-FI-A2D5	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249L	DO41331	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T1266S	TCGA-V1-A8WW	PRAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1266S	DO219365	PRAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.P1260R	DO222414	BTCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.T1246N	DO224661	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246N	DO224731	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246N	DO222553	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246N	DO229013	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246N	DO229016	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO224661	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO224731	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO222553	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO222737	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO229013	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1246S	DO229016	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T1262S	DO224735	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T1262S	DO222553	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T1262S	DO222737	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T1262S	DO229013	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.T1262S	DO229016	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.P1249A	DO222553	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249A	DO222874	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249A	DO229013	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249A	DO229016	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249A	DO228941	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.P1249A	DO228947	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T1256I	DO229016	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.T1256I	DO230659	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.T1256I	DO231140	LAML	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.T1256I	DO228941	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.T1256I	DO228947	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.T1256I	DO229047	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7078
p.D1245V	DO23498	LINC	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.S1267R	SIDM00087	Plasma Cell Myeloma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0833
p.S1267R	SIDM00694	Other Solid Cancers	GDSC	AETSS	DEG_SPOP_SBC_1	0.0833
p.S1267R	SIDM01409	Bladder Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0833
p.L1268F	SIDM00665	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.0556
p.L1268F	ACH-000616	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.0556
p.L1268F	Hs746T	stomach	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of AETSS