DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10688:10692

E3 ligase: SPOP

DEGRON score: 0.9245

ASA_SCORE: 94.26

COIL: 0.8994

CONS_SCORE: 0

DSS_SCORE: 0.6051

HELIX: 0.019

FCONS_SCORE: 0

RIG_SCORE: 0.6961

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F10701L	TCGA-06-5416	GBM	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.F10701L	DO10880	GBM	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.E10689D	TCGA-AP-A1DV	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.5647
p.E10689D	DO43186	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.5647
p.E10689K	TCGA-D3-A8GQ	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.591
p.E10689K	DO51246	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.591
p.N10700I	DO233859	GACA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.T10682K	DO228978	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1667
p.R10696K	DO229177	LMS	ICGC	AETSS	DEG_SPOP_SBC_1	0.2222
p.F10701Y	DO222494	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.P10687L	DO32849	PACA	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.P10699S	SIDM00119	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1389
p.P10699S	SIDM00516	Melanoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1389
p.P10699S	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1389
p.T10697I	SIDM00127	Oral Cavity Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T10697I	ACH-002250	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1944
p.T10697I	JHU-022	upper_aerodigestive_tract	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1944
p.T10681S	SIDM00741	Small Cell Lung Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1389
p.T10681S	ACH-000431	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1389
p.T10681S	NCI-H1694	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1389
p.W10683C	SIDM00118	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1944
p.W10683C	ACH-001081	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1944
p.W10683C	HCC2998	large_intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons