DegronMD - Q9Y4K4(MAP4K5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E442D	TCGA-AP-A0LM	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.5647
p.E442D	DO43306	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.5647
p.V440L	TCGA-BC-A69H	LIHC	TCGA	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.V440L	DO44927	LIHC	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	TCGA-FB-AAPU	PAAD	TCGA	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	DO229005	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	DO218966	PAAD	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM00465	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM00568	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM00997	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM00274	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM01439	Hepatocellular Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM01511	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM00170	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000047	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000247	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000321	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000537	Liver Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000682	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-000746	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-001306	Thyroid Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-001393	Breast Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-001532	Rhabdoid	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-001609	Brain Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-001647	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-002041	Thyroid Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.I446V	ACH-002183	Ovarian Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.3056
p.S445C	TCGA-K4-A83P	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.8652
p.S445C	DO49787	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.8652
p.D450N	DO223058	ESCA	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1944
p.S434R	DO233840	GACA	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5833
p.A441E	DO229018	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation altering degron motif	0.7701
p.S453L	SIDM00680	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.S453L	ACH-000957	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.S453L	LS-180	large intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation rewiring degron network	0.1111
p.S433I	SIDM00217	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5556
p.S433I	ACH-000999	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5556
p.S433I	SNU-1040	large intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	441:445	Mutation blocking phosphorylation signal	0.5556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP4K5

UniProt ID: Q9Y4K4

Entrez ID: 11183

Protein name: Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MAP4K5 in