DegronMD

Uniprot ID: Q9Y4K4

Source protein: Mitogen-activated protein kinase kinase kinase kinase 5

Source gene: MAP4K5

Class: DEG_SPOP_SBC_1

Location: 441:445

E3 ligase: SPOP

DEGRON score: 0.9965

ASA_SCORE: 73.58

COIL: 0.8106

CONS_SCORE: 0.2776

DSS_SCORE: 0.6294

HELIX: 0.079

FCONS_SCORE: 0.8126

RIG_SCORE: 0.6519

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E442D	TCGA-AP-A0LM	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.5647
p.E442D	DO43306	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.5647
p.V440L	TCGA-BC-A69H	LIHC	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.V440L	DO44927	LIHC	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	TCGA-FB-AAPU	PAAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	DO229005	COCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	DO218966	PAAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM00465	Ovarian Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM00568	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM00997	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM00274	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM01439	Hepatocellular Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM01511	Gastric Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM00170	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	SIDM01691	Chronic Myelogenous Leukemia	GDSC	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000047	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000247	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000321	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000537	Liver Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000682	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-000746	Gastric Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-001306	Thyroid Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-001393	Breast Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-001532	Rhabdoid	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-001609	Brain Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-001647	Leukemia	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-002041	Thyroid Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.I446V	ACH-002183	Ovarian Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.3056
p.S445C	TCGA-K4-A83P	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.8652
p.S445C	DO49787	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.8652
p.D450N	DO223058	ESCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.S434R	DO233840	GACA	ICGC	AETSS	DEG_SPOP_SBC_1	0.5833
p.A441E	DO229018	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7701
p.S453L	SIDM00680	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.1111
p.S453L	ACH-000957	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.1111
p.S453L	LS-180	large_intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	0.1111
p.S433I	SIDM00217	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.5556
p.S433I	ACH-000999	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.5556
p.S433I	SNU-1040	large_intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with MAP4K5 mutations

All proteins holding degron of AETSS