DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 3279:3283

E3 ligase: SPOP

DEGRON score: 0.9508

ASA_SCORE: 97.02

COIL: 0.9108

CONS_SCORE: 0.293

DSS_SCORE: 0.8789

HELIX: 0.0694

FCONS_SCORE: 0.7768

RIG_SCORE: 0.5328

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3270L	TCGA-17-Z031	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.H3278Y	TCGA-86-8278	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.H3278Y	DO26308	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.A3288E	TCGA-A5-A0G2	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1944
p.A3288E	DO41235	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1944
p.S3283F	TCGA-A8-A07G	BRCA	TCGA	AETSS	DEG_SPOP_SBC_1	0.9093
p.S3283F	DO2870	BRCA	ICGC	AETSS	DEG_SPOP_SBC_1	0.9093
p.R3277C	TCGA-BR-4370	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.R3277C	TCGA-CG-5730	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.R3277C	DO38499	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.R3277C	DO38324	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.A3279T	TCGA-CG-4469	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.7139
p.A3279T	TCGA-E6-A1LZ	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	0.7139
p.A3279T	DO228960	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A3279T	DO38507	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.A3279T	DO41398	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	0.7139
p.R3270H	TCGA-CR-7371	HNSC	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270H	TCGA-DD-A4NH	LIHC	TCGA	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270H	DO15454	HNSC	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270H	DO44907	LIHC	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.S3271C	TCGA-DG-A2KM	CESC	TCGA	AETSS	DEG_SPOP_SBC_1	0.1111
p.S3271C	DO51597	CESC	ICGC	AETSS	DEG_SPOP_SBC_1	0.1111
p.G3285E	TCGA-EE-A2MM	SKCM	TCGA	AETSS	DEG_SPOP_SBC_1	0.2778
p.G3285E	DO222678	MELA	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.G3285E	DO37770	SKCM	ICGC	AETSS	DEG_SPOP_SBC_1	0.2778
p.Q3293E	TCGA-F5-6863	READ	TCGA	AETSS	DEG_SPOP_SBC_1	0.0556
p.Q3293E	DO37042	READ	ICGC	AETSS	DEG_SPOP_SBC_1	0.0556
p.G3284R	TCGA-MP-A4TF	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.3056
p.G3284R	DO45316	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.3056
p.A3279G	TCGA-RD-A8N6	STAD	TCGA	AETSS	DEG_SPOP_SBC_1	0.754
p.A3279G	DO50140	STAD	ICGC	AETSS	DEG_SPOP_SBC_1	0.754
p.E3280K	TCGA-ZJ-AAXD	CESC	TCGA	AETSS	DEG_SPOP_SBC_1	0.591
p.E3280K	DO219754	CESC	ICGC	AETSS	DEG_SPOP_SBC_1	0.591
p.E3280K	SIDM00630	Breast Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.591
p.E3280K	ACH-000876	Breast Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.591
p.R3270S	DO228950	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270S	DO229052	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270S	DO229051	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270S	AN3-CA	endometrium	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0833
p.R3270S	SK-MEL-2	skin	COSMIC	AETSS	DEG_SPOP_SBC_1	0.0833
p.E3280Q	DO228960	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.5633
p.Q3293K	DO229026	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.0556
p.T3281N	DO229036	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	0.8166
p.T3276S	SIDM00405	B-Cell Non-Hodgkin's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	0.25
p.T3276S	ACH-000365	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	0.25
p.T3276S	SU-DHL-4	haematopoietic_and_lymphoid_tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	0.25
p.R3277L	SIDM01526	Mesothelioma	GDSC	AETSS	DEG_SPOP_SBC_1	0.2778
p.R3277L	ACH-000086	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SPOP_SBC_1	361:365	AETSS	SPOP	0.9876	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	1010:1014	AETSS	SPOP	0.7759	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3279:3283	AETSS	SPOP	0.9508	More...
Q5HY92	Fidgetin	DEG_SPOP_SBC_1	369:373	AETSS	SPOP	0.9725	More...
Q5QJE6	Deoxynucleotidyltransferase terminal-interacting protein 2	DEG_SPOP_SBC_1	186:190	AETSS	SPOP	0.989	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1254:1258	AETSS	SPOP	0.6614	More...
Q8N307	Mucin-20	DEG_SPOP_SBC_1	62:66	AETSS	SPOP	0.8974	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10688:10692	AETSS	SPOP	0.9245	More...
Q9P2H0	Centrosomal protein of 126 kDa	DEG_SPOP_SBC_1	541:545	AETSS	SPOP	0.8543	More...
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	DEG_SPOP_SBC_1	441:445	AETSS	SPOP	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AETSS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of AETSS