DegronMD - Q5HY92(FIGN)

FUNCTION: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, that may lead to the suppression of microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cell... View more >>

GO - Biological processes (BP): cell cycle [GO:0007049]; cell division [GO:0051301]

GO - Molecular function (MF): ATP binding [GO:0005524]; ATP hydrolysis activity [GO:0016887]; microtubule-severing ATPase activity [GO:0008568]; protein C-terminus binding [GO:0008022]

GO - Cellular component (CC): cytoplasm [GO:0005737]; microtubule [GO:0005874]; microtubule organizing center [GO:0005815]; nuclear matrix [GO:0016363]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S453F	TCGA-D3-A8GM	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	TCGA-EE-A2GC	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	DO37839	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	DO50288	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.A449E	TCGA-2H-A9GF	ESCA	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7701
p.T400I	TCGA-BH-A0BP	BRCA	TCGA	PPSY	ITCH	401:404	Mutation blocking phosphorylation signal	0.75
p.T400I	DO4056	BRCA	ICGC	PPSY	ITCH	401:404	Mutation blocking phosphorylation signal	0.75
p.T167A	TCGA-D5-6927	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7139
p.T167A	DO10332	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7139
p.T451A	SIDM00623	Other Blood Cancers	GDSC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.T451A	ACH-002339	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.T451A	Mo-T	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.S165N	TCGA-NH-A5IV	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7069
p.S165N	DO49095	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7069
p.P402S	TCGA-49-6761	LUAD	TCGA	PPSY	ITCH	401:404	Mutation altering degron motif	0.6752
p.P402S	DO24566	LUAD	ICGC	PPSY	ITCH	401:404	Mutation altering degron motif	0.6752
p.L176F	TCGA-2F-A9KR	BLCA	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.L176F	DO48424	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.L176F	DO51862	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.K377E	TCGA-AY-4071	COAD	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation substituting flanking lysine	0.3333

Showing 1 to 20 of 97 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIGN

UniProt ID: Q5HY92

Entrez ID: 55137

Protein name: Fidgetin

External links: UniprotKB HGNC RefSeq COSMIC

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