DegronMD - Q5HY92(FIGN)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P378Q	TCGA-09-2044	OV	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.P378Q	DO28923	OV	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.P441T	TCGA-29-2427	OV	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.P441T	TCGA-61-1727	OV	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.P441T	DO229045	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.P441T	DO31594	OV	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.P441T	DO29960	OV	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1111
p.L176F	TCGA-2F-A9KR	BLCA	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.L176F	DO48424	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.L176F	DO51862	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.587
p.A449E	TCGA-2H-A9GF	ESCA	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7701
p.P402S	TCGA-49-6761	LUAD	TCGA	PPSY	ITCH	401:404	Mutation altering degron motif	0.6752
p.P402S	DO24566	LUAD	ICGC	PPSY	ITCH	401:404	Mutation altering degron motif	0.6752
p.R361L	TCGA-49-AARO	LUAD	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361L	DO218924	LUAD	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.Q183E	TCGA-A2-A0YK	BRCA	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.1389
p.Q183E	DO2836	BRCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.1389
p.R448C	TCGA-A5-A1OF	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	TCGA-EE-A29L	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	DO222599	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	DO37835	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	DO42568	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	SIDM00024	Non-Cancerous	GDSC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	SIDM00429	B-Lymphoblastic Leukemia	GDSC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	ACH-000938	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.R448C	NALM-6	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.3056
p.T379M	TCGA-AX-A1C5	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.T379M	DO41422	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.T379M	ACH-000586	Lung Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.T379M	NCI-H1876	lung	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.S439Y	TCGA-AX-A2HC	UCEC	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0556
p.S439Y	DO41572	UCEC	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.0556
p.K377E	TCGA-AY-4071	COAD	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation substituting flanking lysine	0.3333
p.K377E	DO9146	COAD	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation substituting flanking lysine	0.3333
p.F376C	TCGA-B5-A11E	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.F376C	DO41644	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.S162I	TCGA-BA-4076	HNSC	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.25
p.S162I	DO14502	HNSC	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.25
p.T400I	TCGA-BH-A0BP	BRCA	TCGA	PPSY	ITCH	401:404	Mutation blocking phosphorylation signal	0.75
p.T400I	DO4056	BRCA	ICGC	PPSY	ITCH	401:404	Mutation blocking phosphorylation signal	0.75
p.R361W	TCGA-BK-A6W3	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361W	TCGA-BS-A0UV	UCEC	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361W	TCGA-DK-A6AW	BLCA	TCGA	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361W	DO48566	BLCA	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361W	DO50076	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.R361W	DO42793	UCEC	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1111
p.S453F	TCGA-D3-A8GM	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	TCGA-EE-A2GC	SKCM	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	DO37839	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.S453F	DO50288	SKCM	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7982
p.T167A	TCGA-D5-6927	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7139
p.T167A	DO10332	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7139
p.P181S	TCGA-EY-A1GO	UCEC	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.1944
p.P181S	DO41392	UCEC	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.1944
p.S456F	TCGA-JW-A5VL	CESC	TCGA	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.25
p.S456F	DO49976	CESC	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.25
p.S165N	TCGA-NH-A5IV	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7069
p.S165N	DO49095	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation altering degron motif	0.7069
p.R414K	DO50339	ESAD	ICGC	PPSY	ITCH	401:404	Mutation rewiring degron network	0.0556
p.R414G	DO50339	ESAD	ICGC	PPSY	ITCH	401:404	Mutation rewiring degron network	0.0556
p.G412E	DO233830	GACA	ICGC	PPSY	ITCH	401:404	Mutation rewiring degron network	0.1111
p.L382I	DO229037	LICA	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0833
p.D458E	DO229009	LICA	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.1944
p.S156R	DO48719	LIRI	ICGC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.0833
p.H455Y	DO222868	MELA	ICGC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation rewiring degron network	0.2778
p.M383V	DO36556	READ	ICGC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.S368N	SIDM00845	Burkitt's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368N	SIDM00035	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368N	SIDM01519	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368N	ACH-000992	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368N	Daudi	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S368N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.T359S	SIDM00845	Burkitt's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	SIDM00035	Thyroid Gland Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	SIDM01519	Head and Neck Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	ACH-000786	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	ACH-000992	Head and Neck Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T359S	Daudi	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.0556
p.T451A	SIDM00623	Other Blood Cancers	GDSC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.T451A	ACH-002339	Leukemia	CCLE	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.T451A	Mo-T	haematopoietic and lymphoid tissue	COSMIC	AATSS	DEG_SPOP_SBC_1	449:453	Mutation altering degron motif	0.7139
p.A186T	SIDM00660	Colorectal Carcinoma	GDSC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.0556
p.A186T	ACH-000985	Colon/Colorectal Cancer	CCLE	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.0556
p.A186T	LS-411N	large intestine	COSMIC	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.0556
p.N363Y	SIDM00282	Colorectal Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.N363Y	ACH-000998	Colon/Colorectal Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.N363Y	CW-2	large intestine	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1667
p.L374V	SIDM01188	Pancreatic Carcinoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.L374V	ACH-000114	Pancreatic Cancer	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.L374V	SU8686	pancreas	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.P378L	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.P378L	ACH-001498	Lymphoma	CCLE	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.P378L	Farage	haematopoietic and lymphoid tissue	COSMIC	AETSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.1944
p.R397S	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	PPSY	ITCH	401:404	Mutation rewiring degron network	0.2222
p.R397S	ACH-000845	Lung Cancer	CCLE	PPSY	ITCH	401:404	Mutation rewiring degron network	0.2222
p.T159A	ACH-001818	Bone Cancer	CCLE	SSTCGSHTVPSL	DEG_COP1_1	165:176	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FIGN

UniProt ID: Q5HY92

Entrez ID: 55137

Protein name: Fidgetin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FIGN in