DegronMD

Uniprot ID: Q5HY92

Source protein: Fidgetin

Source gene: FIGN

Class: DEG_COP1_1

Location: 165:176

E3 ligase: COP1

DEGRON score: 0.992

ASA_SCORE: 71.2167

COIL: 0.794

CONS_SCORE: 0.4804

DSS_SCORE: 0.4648

HELIX: 0.1651

FCONS_SCORE: 1.1293

RIG_SCORE: 0.6418

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L176F	TCGA-2F-A9KR	BLCA	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.587
p.L176F	DO48424	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.587
p.L176F	DO51862	BLCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.587
p.Q183E	TCGA-A2-A0YK	BRCA	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.1389
p.Q183E	DO2836	BRCA	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.1389
p.S162I	TCGA-BA-4076	HNSC	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.25
p.S162I	DO14502	HNSC	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.25
p.T167A	TCGA-D5-6927	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.7139
p.T167A	DO10332	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.7139
p.P181S	TCGA-EY-A1GO	UCEC	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.1944
p.P181S	DO41392	UCEC	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.1944
p.S165N	TCGA-NH-A5IV	COAD	TCGA	SSTCGSHTVPSL	DEG_COP1_1	0.7069
p.S165N	DO49095	COAD	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.7069
p.S156R	DO48719	LIRI	ICGC	SSTCGSHTVPSL	DEG_COP1_1	0.0833
p.A186T	SIDM00660	Colorectal Carcinoma	GDSC	SSTCGSHTVPSL	DEG_COP1_1	0.0556
p.A186T	ACH-000985	Colon/Colorectal Cancer	CCLE	SSTCGSHTVPSL	DEG_COP1_1	0.0556
p.A186T	LS-411N	large_intestine	COSMIC	SSTCGSHTVPSL	DEG_COP1_1	0.0556
p.T159A	ACH-001818	Bone Cancer	CCLE	SSTCGSHTVPSL	DEG_COP1_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HY92	Fidgetin	DEG_COP1_1	165:176	SSTCGSHTVPSL	COP1	0.992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons