DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 1384:1390

E3 ligase: BTRC

DEGRON score: 0.9668

ASA_SCORE: 101.7

COIL: 0.9563

CONS_SCORE: 0.4924

DSS_SCORE: 0.8042

HELIX: 0.021

FCONS_SCORE: 1.3242

RIG_SCORE: 0.507

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1400R	TCGA-3N-A9WC	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.G1400R	DO51234	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.G1386E	TCGA-A8-A08G	BRCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7199
p.G1386E	DO3763	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7199
p.S1398R	TCGA-BR-A4QL	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.S1398R	DO38723	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.R1388L	TCGA-D6-A74Q	HNSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.R1388L	DO52087	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.A1378G	TCGA-HT-A616	LGG	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.A1378G	DO48605	LGG	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.A1381S	TCGA-SL-A6JA	UCEC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.A1381S	DO219787	UCEC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.G1374V	TCGA-VQ-A8P5	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.G1374V	DO51763	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.R1388Q	TCGA-VQ-A8PC	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R1388Q	DO217844	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R1388Q	DO51767	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R1383K	TCGA-VS-A8EK	CESC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.R1383K	DO51623	CESC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.R1376G	DO229010	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.R1376G	DO229016	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.R1376G	DO229003	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.R1376G	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.R1376G	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G1374A	DO234401	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.V1395A	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.V1395A	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.T1396S	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.N1397D	DO15046	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.N1397D	SIDM01090	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.N1397D	SIDM00210	Ovarian Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.N1397D	SIDM00863	Burkitt's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.S1390Y	DO228945	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S1390Y	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S1390Y	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S1390Y	SIDM00479	Esophageal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.H1387Y	SIDM01126	Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.6118
p.H1387Y	SIDM00846	Cervical Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.6118
p.H1387Y	SIDM00844	Burkitt's Lymphoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.6118
p.E1399D	SIDM01045	Endometrial Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.E1399D	ACH-000978	Endometrial/Uterine Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.E1399D	EN	endometrium	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.V1395I	SIDM00280	Gastric Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.V1395I	ACH-000560	Gastric Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.V1395I	ECC10	stomach	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.H1375Y	SIDM00217	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.H1375Y	ACH-000999	Colon/Colorectal Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.H1375Y	SNU-1040	large_intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHRGS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of DSGHRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SCF_TRCP1_1	736:742	DSGHRGS	BTRC	0.8901	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	1384:1390	DSGHRGS	BTRC	0.9668	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	2357:2363	DSGHRGS	BTRC	0.9694	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	3653:3659	DSGHRGS	BTRC	0.9646	More...