DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 2357:2363

E3 ligase: BTRC

DEGRON score: 0.9694

ASA_SCORE: 101.1714

COIL: 0.9611

CONS_SCORE: 0.5801

DSS_SCORE: 0.824

HELIX: 0.0217

FCONS_SCORE: 1.345

RIG_SCORE: 0.5006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G2349R	TCGA-02-2466	GBM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G2349R	DO13480	GBM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G2349R	SIDM01128	Small Cell Lung Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G2373E	TCGA-21-1079	LUSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.G2373E	DO26846	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.Q2367H	TCGA-64-5779	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.2222
p.Q2367H	DO24930	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.2222
p.H2360Q	TCGA-B8-4148	KIRC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.647
p.H2360Q	DO19168	KIRC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.647
p.G2349E	TCGA-D9-A6EC	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G2349E	DO50291	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G2359R	TCGA-EE-A2MR	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.G2359R	DO37819	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.R2356S	DO48451	BLCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.A2354V	DO50307	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO224778	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO51036	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO51037	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO51002	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO229028	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2366T	DO52338	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S2363Y	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S2363Y	DO229056	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S2364R	ECC10	stomach	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.A2354T	K-562	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons