DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 3653:3659

E3 ligase: BTRC

DEGRON score: 0.9646

ASA_SCORE: 102.0571

COIL: 0.9633

CONS_SCORE: 0.491

DSS_SCORE: 0.824

HELIX: 0.0193

FCONS_SCORE: 1.1027

RIG_SCORE: 0.5006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S3659T	TCGA-AP-A051	UCEC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6005
p.S3659T	DO42673	UCEC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6005
p.G3645R	TCGA-DA-A95Z	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G3645R	DO219481	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G3645R	ACH-000938	Leukemia	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G3645R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G3655E	TCGA-EB-A551	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7199
p.G3655E	DO47453	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7199
p.G3655R	TCGA-EB-A551	SKCM	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.G3655R	DO47453	SKCM	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.E3668K	TCGA-PQ-A6FN	BLCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.E3668K	DO48579	BLCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.S3662T	DO222785	COCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO228494	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO228712	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO228740	GACA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO50988	LAML	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO228941	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO224558	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO224610	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO52363	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S3662T	DO52365	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.A3664D	DO231179	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1944
p.G3669E	DO218849	SKCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.E3668D	ACH-000238	Head and Neck Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.S3660R	ACH-000560	Gastric Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons