DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 736:742

E3 ligase: BTRC

DEGRON score: 0.8901

ASA_SCORE: 102.4857

COIL: 0.9586

CONS_SCORE: 0.1923

DSS_SCORE: 0.8147

HELIX: 0.0249

FCONS_SCORE: 1

RIG_SCORE: 0.5032

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G738R	TCGA-57-1992	OV	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.G738R	DO32247	OV	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.R740L	TCGA-67-3771	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.R740L	DO25797	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.S742Y	DO229055	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S742Y	DO229208	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S742Y	DO229250	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.R740G	TCGA-DD-AAC8	LIHC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6457
p.R740G	DO52193	LIHC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6457
p.R740Q	TCGA-CR-6473	HNSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R740Q	DO14228	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.S743G	TCGA-CD-A4MG	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.S743G	DO48009	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.V734F	TCGA-BH-A0B1	BRCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.2778
p.V734F	DO4837	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.2778
p.S745R	SIDM00282	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S745R	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S745R	CW-2	large_intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S732F	DO222743	MELA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.2222
p.T748S	TCGA-05-4424	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229057	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229059	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229061	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO23672	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons