DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SCF_TRCP1_1

Location: 736:742

E3 ligase: BTRC

DEGRON score: 0.8901

ASA_SCORE: 102.4857

COIL: 0.9586

CONS_SCORE: 0.1923

DSS_SCORE: 0.8147

HELIX: 0.0249

FCONS_SCORE: 1

RIG_SCORE: 0.5032

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T748S	TCGA-05-4424	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229030	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229057	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229059	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO229061	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	DO23672	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	SIDM00150	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.T748S	KM12	large_intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.1667
p.G738R	TCGA-57-1992	OV	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.G738R	DO32247	OV	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7568
p.Q729K	TCGA-63-A5MW	LUSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.Q729K	DO219169	LUSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1389
p.R740L	TCGA-67-3771	LUAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.R740L	DO25797	LUAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.7316
p.V734F	TCGA-BH-A0B1	BRCA	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.2778
p.V734F	DO4837	BRCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.2778
p.S743G	TCGA-CD-A4MG	STAD	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.S743G	DO48009	STAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.3056
p.R740Q	TCGA-CR-6473	HNSC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R740Q	DO14228	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6218
p.R740G	TCGA-DD-AAC8	LIHC	TCGA	DSGHRGS	DEG_SCF_TRCP1_1	0.6457
p.R740G	DO52193	LIHC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.6457
p.G728R	DO234263	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G728R	DO234362	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G728R	DO234417	ESAD	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.G728R	SIDM01090	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.H727N	DO15591	HNSC	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.0833
p.S750N	DO228945	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.S750N	DO228950	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.S750N	DO229057	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.S750N	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.1111
p.S742Y	DO229055	LICA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S742Y	DO229208	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S742Y	DO229250	THCA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.712
p.S732F	DO222743	MELA	ICGC	DSGHRGS	DEG_SCF_TRCP1_1	0.2222
p.G726R	SIDM00393	Gastric Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.0556
p.S745R	SIDM00282	Colorectal Carcinoma	GDSC	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S745R	ACH-000998	Colon/Colorectal Cancer	CCLE	DSGHRGS	DEG_SCF_TRCP1_1	0.25
p.S745R	CW-2	large_intestine	COSMIC	DSGHRGS	DEG_SCF_TRCP1_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSGHRGS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of DSGHRGS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P20930	Filaggrin	DEG_SCF_TRCP1_1	736:742	DSGHRGS	BTRC	0.8901	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	1384:1390	DSGHRGS	BTRC	0.9668	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	2357:2363	DSGHRGS	BTRC	0.9694	More...
P20930	Filaggrin	DEG_SCF_TRCP1_1	3653:3659	DSGHRGS	BTRC	0.9646	More...