DegronMD

Uniprot ID: P20930

Source protein: Filaggrin

Source gene: FLG

Class: DEG_SPOP_SBC_1

Location: 3950:3954

E3 ligase: SPOP

DEGRON score: 0.969

ASA_SCORE: 104.8

COIL: 0.9698

CONS_SCORE: 0.2888

DSS_SCORE: 0.6574

HELIX: 0.0192

FCONS_SCORE: 0.9356

RIG_SCORE: 0.5199

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3948C	TCGA-06-0213	GBM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2778
p.G3948C	TCGA-17-Z015	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2778
p.G3948C	DO11836	GBM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.R3947C	TCGA-95-A4VN	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947C	TCGA-AP-A1DK	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947C	DO51199	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947C	DO42033	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947C	SIDM00421	T-Cell Non-Hodgkin's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947C	SIDM00407	B-Cell Non-Hodgkin's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.25
p.Q3945R	TCGA-AP-A1DK	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1944
p.Q3945R	DO42033	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.H3941N	TCGA-E6-A1LX	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0833
p.H3941N	DO41020	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.G3943E	TCGA-FW-A3R5	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1389
p.G3943E	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1389
p.H3957R	TCGA-G4-6309	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.25
p.H3957R	DO7810	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.I3944M	TCGA-IN-A7NU	STAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1667
p.I3944M	DO51746	STAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.H3957N	TCGA-ND-A4WC	UCS	TCGA	PHSSS	DEG_SPOP_SBC_1	0.25
p.H3951D	TCGA-VS-A958	CESC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.6577
p.H3951D	DO51639	CESC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.6577
p.E3961Q	DO229101	LMS	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1389
p.R3947L	SIDM01119	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947L	ACH-000775	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.25
p.R3947L	NCI-H727	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.25
p.H3941R	SIDM01090	Colorectal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.H3941R	SIDM00210	Ovarian Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.H3941R	SIDM00863	Burkitt's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.T3963N	SIDM00882	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.T3963N	ACH-002089	Lung Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0833
p.T3963N	201T	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.T3963N	HCC1419	breast	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with FLG mutations

All proteins holding degron of PHSSS