DegronMD - Q8NEL9(DDHD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D81Y	TCGA-05-4382	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.3056
p.D81Y	DO24900	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.3056
p.R589Q	TCGA-2W-A8YY	CESC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1944
p.R589Q	DO223732	CESC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1944
p.R577Q	TCGA-2W-A8YY	CESC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.7329
p.R577Q	DO223732	CESC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.7329
p.T219S	TCGA-33-4533	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.T219S	DO27572	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.Y89C	TCGA-49-AAR2	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation blocking phosphorylation signal	0.5278
p.Y89C	DO218918	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation blocking phosphorylation signal	0.5278
p.E62K	TCGA-93-8067	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1944
p.E62K	DO25113	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1944
p.S792Y	TCGA-A5-A0G1	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0556
p.S573R	TCGA-A5-A0G1	UCEC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.S573R	DO42472	UCEC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.25
p.C83R	TCGA-AA-A03J	COAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.25
p.C83R	DO10467	COAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.25
p.E87D	TCGA-AJ-A5DW	UCEC	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1389
p.E87D	TCGA-EB-A4OY	SKCM	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1389
p.E87D	DO47261	SKCM	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1389
p.E87D	DO50075	UCEC	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1389
p.G220D	TCGA-BR-4201	STAD	TCGA	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.3056
p.G220D	DO38707	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.3056
p.K591E	TCGA-CN-6010	HNSC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation substituting flanking lysine	0.25
p.K591E	DO14766	HNSC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation substituting flanking lysine	0.25
p.R589W	TCGA-DM-A1HB	COAD	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1944
p.N88T	TCGA-OR-A5LI	ACC	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.1111
p.S805C	TCGA-UB-A7MB	LIHC	TCGA	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7541
p.L78V	DO230323	COCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation altering degron motif	0.5654
p.P218L	DO229016	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.25
p.A57S	DO223046	ESCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.0556
p.A234S	DO222586	ESCA	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.T805K	DO229019	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7306
p.L590M	DO229027	LICA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1667
p.T219K	DO229027	LICA	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.2778
p.S812C	DO52318	LIHC	ICGC	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.1667
p.E582D	DO222644	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.5647
p.E582K	DO222644	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.591
p.L579F	DO222662	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.587
p.D232G	DO232224	PBCA	ICGC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1389
p.H66Y	DO229272	THCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.3056
p.S799Y	DO42472	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.25
p.R815I	SIDM00087	Plasma Cell Myeloma	GDSC	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.0833
p.R577L	SIDM01129	Small Cell Lung Carcinoma	GDSC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.8428
p.R577L	ACH-000816	Lung Cancer	CCLE	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.8428
p.R577L	NCI-H524	lung	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.8428
p.P63L	SIDM00516	Melanoma	GDSC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.2222
p.P63L	ACH-002166	Skin Cancer	CCLE	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.2222
p.P63L	MZ7-mel	skin	COSMIC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	67:80	Mutation rewiring degron network	0.2222
p.H803R	SIDM00792	Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation altering degron motif	0.7133
p.A234T	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.A234T	SIDM00561	Other Blood Cancers	GDSC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.A234T	ACH-002274	Leukemia	CCLE	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.A234T	TE-9	oesophagus	COSMIC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.A234T	MLMA	haematopoietic and lymphoid tissue	COSMIC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.0833
p.L809P	ACH-001391	Breast Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	802:806	Mutation rewiring degron network	0.25
p.R584L	NCI-H524	lung	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.8428
p.E579G	EVSA-T	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.7199
p.W571L	OCUB-M	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.1944
p.W578L	OCUB-M	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.7015
p.S216I	COR-L321	NS	COSMIC	PASSS	DEG_SPOP_SBC_1	221:225	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DDHD1

UniProt ID: Q8NEL9

Entrez ID: 80821

Protein name: Phospholipase DDHD1 (EC 3.1.1.-) (DDHD domain-containing protein 1) (Phosphatidic acid-preferring phospholipase A1 homolog) (PA-PLA1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DDHD1 in