DegronMD

Uniprot ID: Q8NEL9

Source protein: Phospholipase DDHD1

Source gene: DDHD1

Class: DEG_ODPH_VHL_1

Location: 67:80

E3 ligase: VHL

DEGRON score: 0.9413

ASA_SCORE: 69.7571

COIL: 0.7694

CONS_SCORE: 0.2323

DSS_SCORE: 0.4584

HELIX: 0.1628

FCONS_SCORE: 0.9045

RIG_SCORE: 0.6713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D81Y	TCGA-05-4382	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.3056
p.D81Y	DO24900	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.3056
p.Y89C	TCGA-49-AAR2	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.5278
p.Y89C	DO218918	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.5278
p.E62K	TCGA-93-8067	LUAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1944
p.E62K	DO25113	LUAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1944
p.C83R	TCGA-AA-A03J	COAD	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.25
p.C83R	DO10467	COAD	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.25
p.E87D	TCGA-AJ-A5DW	UCEC	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1389
p.E87D	TCGA-EB-A4OY	SKCM	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1389
p.E87D	DO47261	SKCM	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1389
p.E87D	DO50075	UCEC	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1389
p.N88T	TCGA-OR-A5LI	ACC	TCGA	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.1111
p.L78V	DO230323	COCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.5654
p.A57S	DO223046	ESCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.0556
p.H66Y	DO229272	THCA	ICGC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.3056
p.P63L	SIDM00516	Melanoma	GDSC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.2222
p.P63L	ACH-002166	Skin Cancer	CCLE	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.2222
p.P63L	MZ7-mel	skin	COSMIC	LAPGTDDHNHHLAL	DEG_ODPH_VHL_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEL9	Phospholipase DDHD1	DEG_ODPH_VHL_1	67:80	LAPGTDDHNHHLAL	VHL	0.9413	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons