DegronMD

Uniprot ID: Q8NEL9

Source protein: Phospholipase DDHD1

Source gene: DDHD1

Class: DEG_APCC_DBOX_1

Location: 576:584

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6943

ASA_SCORE: 82.8889

COIL: 0.363

CONS_SCORE: 0.2994

DSS_SCORE: 0.126

HELIX: 0.6152

FCONS_SCORE: 1.2229

RIG_SCORE: 0.8606

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R589Q	TCGA-2W-A8YY	CESC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	0.1944
p.R589Q	DO223732	CESC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.1944
p.R577Q	TCGA-2W-A8YY	CESC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	0.7329
p.R577Q	DO223732	CESC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.7329
p.S573R	TCGA-A5-A0G1	UCEC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	0.25
p.S573R	DO42472	UCEC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.25
p.K591E	TCGA-CN-6010	HNSC	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	0.25
p.K591E	DO14766	HNSC	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.25
p.R589W	TCGA-DM-A1HB	COAD	TCGA	ERHLLDELY	DEG_APCC_DBOX_1	0.1944
p.L590M	DO229027	LICA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.1667
p.E582D	DO222644	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.5647
p.E582K	DO222644	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.591
p.L579F	DO222662	MELA	ICGC	ERHLLDELY	DEG_APCC_DBOX_1	0.587
p.R577L	SIDM01129	Small Cell Lung Carcinoma	GDSC	ERHLLDELY	DEG_APCC_DBOX_1	0.8428
p.R577L	ACH-000816	Lung Cancer	CCLE	ERHLLDELY	DEG_APCC_DBOX_1	0.8428
p.R577L	NCI-H524	lung	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	0.8428
p.R584L	NCI-H524	lung	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	0.8428
p.E579G	EVSA-T	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	0.7199
p.W571L	OCUB-M	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	0.1944
p.W578L	OCUB-M	breast	COSMIC	ERHLLDELY	DEG_APCC_DBOX_1	0.7015

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8NEL9	Phospholipase DDHD1	DEG_APCC_DBOX_1	576:584	ERHLLDELY	APC,CDC20,FZR1	0.6943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons