DegronMD

Uniprot ID: O60229

Source protein: Kalirin

Source gene: KALRN

Class: DEG_SPOP_SBC_1

Location: 732:736

E3 ligase: SPOP

DEGRON score: 0.9258

ASA_SCORE: 62.24

COIL: 0.6268

CONS_SCORE: 0.3303

DSS_SCORE: 0.5659

HELIX: 0.348

FCONS_SCORE: 1.2179

RIG_SCORE: 0.5738

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K722I	TCGA-17-Z060	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0556
p.V743F	TCGA-69-7978	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1389
p.V743F	DO24920	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1389
p.S738R	TCGA-AA-3663	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2778
p.S738R	DO9346	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.A725T	TCGA-AA-3977	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1389
p.A725T	DO8730	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1389
p.D723N	TCGA-CV-A6JZ	HNSC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0833
p.D723N	DO52076	HNSC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.T726I	TCGA-D1-A17M	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1667
p.T726I	DO43779	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.T727N	TCGA-EO-A3B0	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1944
p.G735R	TCGA-EY-A1GO	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.7568
p.D722H	TCGA-P3-A6SX	HNSC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0556
p.V743D	DO6454	CLLE	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1389
p.I734V	DO234373	ESAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.7076
p.S724W	DO230961	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1111
p.V741A	DO26798	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.R729C	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.T744R	SIDM01958	Esophageal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1111
p.S727T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.S727T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.S727T	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.S727T	SIDM00736	Non-Cancerous	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.K730N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.K730N	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.S735N	ACH-001973	Metastasis	CCLE	PHSSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with KALRN mutations

All proteins holding degron of PHSSS