DegronMD - Q14C86(GAPVD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R759S	TCGA-05-4396	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.R759S	DO23838	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.R754M	TCGA-55-7995	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.R754M	DO45323	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.G764V	TCGA-75-5146	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation altering degron motif	0.6421
p.G764V	DO25228	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation altering degron motif	0.6421
p.R947W	TCGA-A5-A0G2	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation altering degron motif	0.8634
p.R947W	TCGA-EO-A22U	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation altering degron motif	0.8634
p.R937W	TCGA-A6-6780	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.1389
p.R759C	TCGA-AA-3956	COAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.R759C	DO9700	COAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.R759C	SIDM00215	Colorectal Carcinoma	GDSC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.R759C	SNU-283	large intestine	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.G770S	TCGA-B5-A0K2	UCEC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.2222
p.G770S	DO43835	UCEC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.2222
p.P957S	TCGA-BF-AAP2	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.0833
p.D752H	TCGA-CG-4443	STAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1111
p.D752H	DO38779	STAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1111
p.R948H	TCGA-CM-4743	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation altering degron motif	0.8244
p.P471L	TCGA-DK-AA6S	BLCA	TCGA	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation rewiring degron network	0.0833
p.P471L	DO219007	BLCA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation rewiring degron network	0.0833
p.R754S	TCGA-O8-A75V	LIHC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.R754S	DO49716	LIHC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1667
p.P951L	DO8312	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.25
p.D750Y	DO229029	LICA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0556
p.V767F	DO229028	LICA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.3056
p.Q464H	DO229045	LICA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation rewiring degron network	0.2778
p.P459L	DO222702	MELA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.7582
p.P944H	DO47407	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation altering degron motif	0.7694
p.T751M	SIDM02013	Colorectal Carcinoma	GDSC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0833
p.M457I	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.6507
p.M457I	ACH-000562	Lung Cancer	CCLE	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.6507
p.M457I	HCC-78	lung	COSMIC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.6507
p.E776K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0556
p.E776K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.0556
p.P958S	SIDM01039	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.0556
p.P958S	SIDM00704	Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.0556
p.P958S	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.0556
p.P958S	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.0556
p.N461S	SIDM00254	Neuroblastoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.5958
p.N461S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	455:462	Mutation altering degron motif	0.5958
p.L956V	SIDM00721	Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation blocking phosphorylation signal	0.5556
p.L956V	NCI-H250	lung	COSMIC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation blocking phosphorylation signal	0.5556
p.D771E	ACH-000721	Breast Cancer	CCLE	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1944
p.R942C	ACH-001333	Cervical Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.2778
p.R942C	C-33-A	cervix	COSMIC	PHSSS	DEG_SPOP_SBC_1	944:948	Mutation rewiring degron network	0.2778
p.E755K	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	760:766	Mutation rewiring degron network	0.1944

Kaplan plot for GAPVD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAPVD1

UniProt ID: Q14C86

Entrez ID: 26130

Protein name: GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAPVD1 in