DegronMD

Uniprot ID: Q14C86

Source protein: GTPase-activating protein and VPS9 domain-containing protein 1

Source gene: GAPVD1

Class: DEG_SCF_FBW7_1

Location: 455:462

E3 ligase: FBXW7

DEGRON score: 0.9937

ASA_SCORE: 80.8875

COIL: 0.8668

CONS_SCORE: 0.3441

DSS_SCORE: 0.6604

HELIX: 0.0595

FCONS_SCORE: 0.8825

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P471L	TCGA-DK-AA6S	BLCA	TCGA	LEMTPYNT	DEG_SCF_FBW7_1	0.0833
p.P471L	DO219007	BLCA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	0.0833
p.Q464H	DO229045	LICA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	0.2778
p.P459L	DO222702	MELA	ICGC	LEMTPYNT	DEG_SCF_FBW7_1	0.7582
p.M457I	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	0.6507
p.M457I	ACH-000562	Lung Cancer	CCLE	LEMTPYNT	DEG_SCF_FBW7_1	0.6507
p.M457I	HCC-78	lung	COSMIC	LEMTPYNT	DEG_SCF_FBW7_1	0.6507
p.N461S	SIDM00254	Neuroblastoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	0.5958
p.N461S	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	LEMTPYNT	DEG_SCF_FBW7_1	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SCF_FBW7_1	455:462	LEMTPYNT	FBXW7	0.9937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons