DegronMD

Uniprot ID: Q14C86

Source protein: GTPase-activating protein and VPS9 domain-containing protein 1

Source gene: GAPVD1

Class: DEG_SCF_FBW7_1

Location: 760:766

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 82.5857

COIL: 0.9373

CONS_SCORE: 0.3642

DSS_SCORE: 0.5608

HELIX: 0.0437

FCONS_SCORE: 1.0009

RIG_SCORE: 0.6265

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R759S	TCGA-05-4396	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.R759S	DO23838	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.R754M	TCGA-55-7995	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.R754M	DO45323	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.G764V	TCGA-75-5146	LUAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.6421
p.G764V	DO25228	LUAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.6421
p.R759C	TCGA-AA-3956	COAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.R759C	DO9700	COAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.R759C	SIDM00215	Colorectal Carcinoma	GDSC	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.R759C	SNU-283	large_intestine	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.G770S	TCGA-B5-A0K2	UCEC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.2222
p.G770S	DO43835	UCEC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.2222
p.D752H	TCGA-CG-4443	STAD	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.1111
p.D752H	DO38779	STAD	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1111
p.R754S	TCGA-O8-A75V	LIHC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.R754S	DO49716	LIHC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.D750Y	DO229029	LICA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.0556
p.V767F	DO229028	LICA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.3056
p.T751M	SIDM02013	Colorectal Carcinoma	GDSC	PSTPGLS	DEG_SCF_FBW7_1	0.0833
p.E776K	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PSTPGLS	DEG_SCF_FBW7_1	0.0556
p.E776K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	0.0556
p.D771E	ACH-000721	Breast Cancer	CCLE	PSTPGLS	DEG_SCF_FBW7_1	0.1944
p.E755K	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPGLS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SCF_FBW7_1	760:766	PSTPGLS	FBXW7	0.9956	More...
Q6P1X5	Transcription initiation factor TFIID subunit 2	DEG_SCF_FBW7_1	1068:1074	PSTPGLS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons