DegronMD

Uniprot ID: Q6P1X5

Source protein: Transcription initiation factor TFIID subunit 2

Source gene: TAF2

Class: DEG_SCF_FBW7_1

Location: 1068:1074

E3 ligase: FBXW7

DEGRON score: 0.997

ASA_SCORE: 75.4714

COIL: 0.9339

CONS_SCORE: 0.2541

DSS_SCORE: 0.586

HELIX: 0.0399

FCONS_SCORE: 1.0236

RIG_SCORE: 0.6381

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1070A	TCGA-21-5783	LUSC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.825
p.T1070A	DO27437	LUSC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.825
p.G1072W	TCGA-39-5036	LUSC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.6714
p.G1072W	DO27508	LUSC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.6714
p.S1080G	TCGA-85-8350	LUSC	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.S1080G	DO45492	LUSC	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1667
p.H1060Y	TCGA-QB-AA9O	SKCM	TCGA	PSTPGLS	DEG_SCF_FBW7_1	0.1111
p.H1060Y	DO51267	SKCM	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1111
p.N1063Y	DO233790	GACA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.1944
p.L1065I	DO228971	LICA	ICGC	PSTPGLS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SCF_FBW7_1	760:766	PSTPGLS	FBXW7	0.9956	More...
Q6P1X5	Transcription initiation factor TFIID subunit 2	DEG_SCF_FBW7_1	1068:1074	PSTPGLS	FBXW7	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons