DegronMD - Q9C0B5(ZDHHC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E561D	TCGA-A5-A0G2	UCEC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1389
p.E561D	DO233697	GACA	ICGC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1389
p.E561D	DO41235	UCEC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1389
p.G565D	TCGA-A5-A1OF	UCEC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.25
p.G565D	DO42568	UCEC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.25
p.A373T	TCGA-AA-3977	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.A373T	DO8730	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.A373T	DO229250	THCA	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.R377H	TCGA-AF-6655	READ	TCGA	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.R377H	TCGA-BG-A222	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.R377H	DO36895	READ	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.R377H	DO42977	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.R582H	TCGA-AP-A059	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7133
p.R582H	TCGA-OR-A5J5	ACC	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7133
p.K591N	TCGA-AX-A05Z	UCEC	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation substituting flanking lysine	0.2778
p.K591N	DO40884	UCEC	ICGC	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation substituting flanking lysine	0.2778
p.R464H	TCGA-AX-A06F	UCEC	TCGA	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.R464H	DO41752	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.V646I	TCGA-B1-A47M	KIRP	TCGA	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.0556
p.V646I	DO49736	KIRP	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.0556
p.R560L	TCGA-BC-A5W4	LIHC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.R560L	DO44962	LIHC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.S577L	TCGA-CN-6011	HNSC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation blocking phosphorylation signal	0.6944
p.S577L	TCGA-CN-6011	HNSC	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation blocking phosphorylation signal	0.6667
p.S577L	TCGA-YC-A89H	BLCA	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation blocking phosphorylation signal	0.6944
p.S577L	TCGA-YC-A89H	BLCA	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation blocking phosphorylation signal	0.6667
p.T363M	TCGA-D1-A2G0	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.T363M	DO43418	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.T363M	DO43049	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.K374N	TCGA-EE-A183	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation blocking ubiquitination signal	0.7222
p.K374N	DO37715	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation blocking ubiquitination signal	0.7222
p.S587L	TCGA-EE-A3JI	SKCM	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.2778
p.E648V	TCGA-EY-A1GP	UCEC	TCGA	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.1111
p.E648V	DO41265	UCEC	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.1111
p.N465S	TCGA-HV-A7OL	PAAD	TCGA	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1111
p.N465S	DO223710	PAAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1111
p.S590P	TCGA-TM-A84M	LGG	TCGA	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation blocking phosphorylation signal	0.6389
p.S573L	TCGA-YC-A89H	BLCA	TCGA	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.6556
p.G655C	DO44228	BRCA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.3056
p.R485C	DO10140	COAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.R485C	DO47767	STAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.R485C	DO42280	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.R485C	DO42528	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.D366N	DO222884	COCA	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.2778
p.R580Q	DO229003	COCA	ICGC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1667
p.R580Q	DO229003	COCA	ICGC	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.L666M	DO233841	GACA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.25
p.S380I	DO228952	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation blocking phosphorylation signal	0.5556
p.S479I	DO228952	LICA	ICGC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation altering degron motif	0.7341
p.R377L	DO229009	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.1944
p.V646F	DO229009	LICA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.0556
p.S585F	DO222420	MELA	ICGC	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation altering degron motif	0.7982
p.P368L	DO229242	THCA	ICGC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation altering degron motif	0.7582
p.A365P	SIDM00795	Melanoma	GDSC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.A365P	ACH-000219	Skin Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.A365P	ACH-000489	Colon/Colorectal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.25
p.R560H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.R560H	ACH-000920	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.R560H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1111
p.S586F	SIDM01042	Breast Carcinoma	GDSC	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.S586F	ACH-001065	Breast Cancer	CCLE	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.S586F	EVSA-T	breast	COSMIC	PRTSS	DEG_SPOP_SBC_1	581:585	Mutation rewiring degron network	0.3056
p.R464C	SIDM01757	Bladder Carcinoma	GDSC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.R464C	ACH-000741	Bladder Cancer	CCLE	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.0833
p.S673F	ACH-000779	Lung Cancer	CCLE	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.0556
p.E650Q	ACH-001523	Skin Cancer	CCLE	PLLTPKDE	DEG_SCF_FBW7_2	656:663	Mutation rewiring degron network	0.1667
p.D568G	ACH-001669	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.7198
p.D568G	ACH-002238	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.7198
p.D568G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.7198
p.S467N	ACH-001957	Bone Cancer	CCLE	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1667
p.E563K	ACH-002048	Sarcoma	CCLE	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation rewiring degron network	0.1944
p.I487V	GP5d	large intestine	COSMIC	LLTPSDS	DEG_SCF_FBW7_1	473:479	Mutation rewiring degron network	0.1111
p.P571S	SNU-175	large intestine	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	568:574	Mutation altering degron motif	0.6752
p.R373C	SISO	cervix	COSMIC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056
p.R373C	RKN	ovary	COSMIC	PHSSS	DEG_SPOP_SBC_1	368:372	Mutation rewiring degron network	0.3056

Kaplan plot for ZDHHC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZDHHC5

UniProt ID: Q9C0B5

Entrez ID: 25921

Protein name: Palmitoyltransferase ZDHHC5 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 5) (DHHC-5) (Zinc finger protein 375)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZDHHC5 in