DegronMD

Uniprot ID: Q9C0B5

Source protein: Palmitoyltransferase ZDHHC5

Source gene: ZDHHC5

Class: DEG_SCF_TRCP1_1

Location: 568:574

E3 ligase: BTRC

DEGRON score: 0.9472

ASA_SCORE: 57

COIL: 0.7464

CONS_SCORE: 0.2413

DSS_SCORE: 0.8632

HELIX: 0.0196

FCONS_SCORE: 0.9752

RIG_SCORE: 0.5303

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E561D	TCGA-A5-A0G2	UCEC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.1389
p.E561D	DO233697	GACA	ICGC	DSGIQST	DEG_SCF_TRCP1_1	0.1389
p.E561D	DO41235	UCEC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	0.1389
p.G565D	TCGA-A5-A1OF	UCEC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.25
p.G565D	DO42568	UCEC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	0.25
p.R560L	TCGA-BC-A5W4	LIHC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.1111
p.R560L	DO44962	LIHC	ICGC	DSGIQST	DEG_SCF_TRCP1_1	0.1111
p.S577L	TCGA-CN-6011	HNSC	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.6944
p.S577L	TCGA-YC-A89H	BLCA	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.6944
p.S573L	TCGA-YC-A89H	BLCA	TCGA	DSGIQST	DEG_SCF_TRCP1_1	0.6556
p.R580Q	DO229003	COCA	ICGC	DSGIQST	DEG_SCF_TRCP1_1	0.1667
p.R560H	SIDM00958	Chronic Myelogenous Leukemia	GDSC	DSGIQST	DEG_SCF_TRCP1_1	0.1111
p.R560H	ACH-000920	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	0.1111
p.R560H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	0.1111
p.D568G	ACH-001669	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	0.7198
p.D568G	ACH-002238	Leukemia	CCLE	DSGIQST	DEG_SCF_TRCP1_1	0.7198
p.D568G	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	0.7198
p.E563K	ACH-002048	Sarcoma	CCLE	DSGIQST	DEG_SCF_TRCP1_1	0.1944
p.P571S	SNU-175	large_intestine	COSMIC	DSGIQST	DEG_SCF_TRCP1_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SCF_TRCP1_1	568:574	DSGIQST	BTRC	0.9472	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons