DegronMD

Uniprot ID: Q9C0B5

Source protein: Palmitoyltransferase ZDHHC5

Source gene: ZDHHC5

Class: DEG_SCF_FBW7_2

Location: 656:663

E3 ligase: FBXW7

DEGRON score: 0.5829

ASA_SCORE: 84.45

COIL: 0.6869

CONS_SCORE: 0.2431

DSS_SCORE: 0.5459

HELIX: 0.244

FCONS_SCORE: 0.9514

RIG_SCORE: 0.7704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V646I	TCGA-B1-A47M	KIRP	TCGA	PLLTPKDE	DEG_SCF_FBW7_2	0.0556
p.V646I	DO49736	KIRP	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	0.0556
p.E648V	TCGA-EY-A1GP	UCEC	TCGA	PLLTPKDE	DEG_SCF_FBW7_2	0.1111
p.E648V	DO41265	UCEC	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	0.1111
p.G655C	DO44228	BRCA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	0.3056
p.L666M	DO233841	GACA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	0.25
p.V646F	DO229009	LICA	ICGC	PLLTPKDE	DEG_SCF_FBW7_2	0.0556
p.S673F	ACH-000779	Lung Cancer	CCLE	PLLTPKDE	DEG_SCF_FBW7_2	0.0556
p.E650Q	ACH-001523	Skin Cancer	CCLE	PLLTPKDE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SCF_FBW7_2	656:663	PLLTPKDE	FBXW7	0.5829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons