DegronMD

Uniprot ID: Q9C0B5

Source protein: Palmitoyltransferase ZDHHC5

Source gene: ZDHHC5

Class: DEG_SCF_FBW7_1

Location: 473:479

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 70.9

COIL: 0.9117

CONS_SCORE: 0.2646

DSS_SCORE: 0.5842

HELIX: 0.0551

FCONS_SCORE: 1.0308

RIG_SCORE: 0.6448

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R464H	TCGA-AX-A06F	UCEC	TCGA	LLTPSDS	DEG_SCF_FBW7_1	0.0833
p.R464H	DO41752	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.0833
p.N465S	TCGA-HV-A7OL	PAAD	TCGA	LLTPSDS	DEG_SCF_FBW7_1	0.1111
p.N465S	DO223710	PAAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.1111
p.R485C	DO10140	COAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.1667
p.R485C	DO47767	STAD	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.1667
p.R485C	DO42280	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.1667
p.R485C	DO42528	UCEC	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.1667
p.S479I	DO228952	LICA	ICGC	LLTPSDS	DEG_SCF_FBW7_1	0.7341
p.R464C	SIDM01757	Bladder Carcinoma	GDSC	LLTPSDS	DEG_SCF_FBW7_1	0.0833
p.R464C	ACH-000741	Bladder Cancer	CCLE	LLTPSDS	DEG_SCF_FBW7_1	0.0833
p.S467N	ACH-001957	Bone Cancer	CCLE	LLTPSDS	DEG_SCF_FBW7_1	0.1667
p.I487V	GP5d	large_intestine	COSMIC	LLTPSDS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SCF_FBW7_1	473:479	LLTPSDS	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons