DegronMD - O60229(KALRN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K722I	TCGA-17-Z060	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0556
p.V743F	TCGA-69-7978	LUAD	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.V743F	DO24920	LUAD	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.S738R	TCGA-AA-3663	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.S738R	DO9346	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.A725T	TCGA-AA-3977	COAD	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.A725T	DO8730	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.D723N	TCGA-CV-A6JZ	HNSC	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0833
p.D723N	DO52076	HNSC	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0833
p.T726I	TCGA-D1-A17M	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1667
p.T726I	DO43779	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1667
p.T727N	TCGA-EO-A3B0	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.G735R	TCGA-EY-A1GO	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7568
p.D722H	TCGA-P3-A6SX	HNSC	TCGA	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.0556
p.V743D	DO6454	CLLE	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1389
p.I734V	DO234373	ESAD	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7076
p.S724W	DO230961	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1111
p.V741A	DO26798	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.R729C	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.25
p.T744R	SIDM01958	Esophageal Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1111
p.S727T	SIDM00651	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.S727T	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.S727T	SIDM00116	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.S727T	SIDM00736	Non-Cancerous	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.1944
p.K730N	SIDM00438	B-Lymphoblastic Leukemia	GDSC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.K730N	MN-60	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation rewiring degron network	0.2778
p.S735N	ACH-001973	Metastasis	CCLE	PHSSS	DEG_SPOP_SBC_1	732:736	Mutation altering degron motif	0.7069
p.T2227K	COR-L279	lung	COSMIC	QRDFLNALQ	DEG_APCC_DBOX_1	2228:2236	Mutation rewiring degron network	0.3056

Kaplan plot for KALRN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KALRN

UniProt ID: O60229

Entrez ID: 8997

Protein name: Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KALRN in