DegronMD - O14559(ARHGAP33)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A836P	TCGA-20-1685	OV	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.0833
p.S957F	TCGA-2W-A8YY	CESC	TCGA	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0833
p.A956V	TCGA-37-4130	LUSC	TCGA	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0556
p.L818R	TCGA-69-8255	LUAD	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.2222
p.D815Y	TCGA-AA-3955	COAD	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1389
p.R823Q	TCGA-B5-A11Z	UCEC	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation altering degron motif	0.7329
p.R823Q	SIDM00525	Osteosarcoma	GDSC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation altering degron motif	0.7329
p.R823Q	ACH-000359	Bone Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation altering degron motif	0.7329
p.R823Q	MG-63	bone	COSMIC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation altering degron motif	0.7329
p.R672C	TCGA-DI-A0WH	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.Y977H	TCGA-ED-A7PY	LIHC	TCGA	PPPY	ITCH	966:969	Mutation rewiring degron network	0.1111
p.S814G	TCGA-EE-A2MT	SKCM	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1111
p.R820M	TCGA-EO-A22R	UCEC	TCGA	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.2778
p.D972N	TCGA-VQ-A8PB	STAD	TCGA	PPPY	ITCH	966:969	Mutation rewiring degron network	0.25
p.S1187C	DO51896	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.2778
p.S1183C	DO219093	BLCA	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation altering degron motif	0.7541
p.S1279F	DO726	BLCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.25
p.S1279F	DO726	BLCA	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.0833
p.E1280K	DO1076	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.2222
p.E1280K	DO1076	BRCA	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.0556
p.R1284Q	DO1076	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.1111
p.S1279C	DO44129	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.25
p.S1279C	DO44129	BRCA	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.0833
p.S1279C	DO14566	HNSC	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.25
p.S1279C	DO14566	HNSC	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.0833
p.P1190S	DO227842	COCA	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.1944
p.P1190S	DO219501	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.1944
p.S813N	DO222794	COCA	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.0833
p.G824A	DO229005	COCA	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation altering degron motif	0.754
p.P967L	DO234411	ESAD	ICGC	PPPY	ITCH	966:969	Mutation altering degron motif	0.7582
p.S653L	DO48326	ESCA	ICGC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.G1246A	DO223265	HNSC	ICGC	PPAY	ITCH	1239:1242	Mutation rewiring degron network	0.2222
p.S1186F	DO49780	KIRP	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.3056
p.Y974H	DO48477	LIHC	ICGC	PPPY	ITCH	966:969	Mutation rewiring degron network	0.1944
p.L979R	DO25360	LUAD	ICGC	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0556
p.P1271S	DO222843	MELA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation altering degron motif	0.5641
p.E1262D	DO50732	ORCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.1389
p.E1262D	DO50732	ORCA	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.1944
p.S831I	DO50733	ORCA	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.2222
p.R830Q	DO232040	ORCA	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.25
p.Y1270S	DO48957	PBCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation altering degron motif	0.6009
p.Y1270S	DO48957	PBCA	ICGC	PPPY	ITCH	1267:1270	Mutation altering degron motif	0.712
p.G829E	DO37130	READ	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.2778
p.P1179L	DO37474	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.2778
p.P1189S	DO48665	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.2222
p.A1264V	DO47320	SKCM	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation rewiring degron network	0.1944
p.A1264V	DO47320	SKCM	ICGC	PPPY	ITCH	1267:1270	Mutation rewiring degron network	0.25
p.P1240Q	DO47573	SKCM	ICGC	PPAY	ITCH	1239:1242	Mutation altering degron motif	0.7035
p.S1188A	DO38111	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.25
p.S1188F	DO51276	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.25
p.S1184F	DO51235	SKCM	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation altering degron motif	0.7982
p.P1193T	DO47717	STAD	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.1111
p.P1189T	DO39552	THCA	ICGC	PASSS	DEG_SPOP_SBC_1	1181:1185	Mutation rewiring degron network	0.2222
p.P1273S	DO41572	UCEC	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	1269:1276	Mutation altering degron motif	0.6752
p.R833C	DO43843	UCEC	ICGC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.1667
p.P978L	SIDM02029	Colorectal Carcinoma	GDSC	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0833
p.A956T	SIDM01126	Small Cell Lung Carcinoma	GDSC	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0556
p.A956T	ACH-001599	Lung Cancer	CCLE	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0556
p.A956T	NCI-H64	lung	COSMIC	PPPY	ITCH	966:969	Mutation rewiring degron network	0.0556
p.R672H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.R672H	SIDM01608	Endometrial Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.R672H	ACH-000960	Leukemia	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.R672H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.R672H	ACH-001961	Gallbladder Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.R672H	REH	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0556
p.A652T	SIDM00690	Head and Neck Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1667
p.A652T	SIDM00971	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1667
p.A652T	SIDM01133	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1667
p.V667M	SIDM00492	Glioblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.V667M	AM-38	central nervous system	COSMIC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM00316	Glioblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM01372	Pancreatic Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM01394	Kidney Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM01690	Plasma Cell Myeloma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM00173	Head and Neck Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	SIDM00016	Neuroblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.P667R	YH-13	central nervous system	COSMIC	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1944
p.L649F	ACH-000401	Skin Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.0833
p.S670G	ACH-000597	Rhabdoid	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1111
p.S670G	ACH-001200	Rhabdoid	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.1111
p.A664T	ACH-000999	Colon/Colorectal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	658:662	Mutation rewiring degron network	0.2778
p.N818H	H2369	pleura	COSMIC	PTPALS	DEG_SCF_FBW7_1	822:827	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGAP33

UniProt ID: O14559

Entrez ID: 115703

Protein name: Rho GTPase-activating protein 33 (Rho-type GTPase-activating protein 33) (Sorting nexin-26) (Tc10/CDC42 GTPase-activating protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGAP33 in