DegronMD

Uniprot ID: O14559

Source protein: Rho GTPase-activating protein 33

Source gene: ARHGAP33

Class: DEG_SCF_FBW7_1

Location: 1269:1276

E3 ligase: FBXW7

DEGRON score: 0.9983

ASA_SCORE: 76.5875

COIL: 0.8135

CONS_SCORE: 0.4239

DSS_SCORE: 0.6827

HELIX: 0.0291

FCONS_SCORE: 1.18

RIG_SCORE: 0.6147

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1279F	DO726	BLCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.25
p.E1280K	DO1076	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.2222
p.R1284Q	DO1076	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.1111
p.S1279C	DO44129	BRCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.25
p.S1279C	DO14566	HNSC	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.25
p.P1271S	DO222843	MELA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.5641
p.E1262D	DO50732	ORCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.1389
p.Y1270S	DO48957	PBCA	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.6009
p.A1264V	DO47320	SKCM	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.1944
p.P1273S	DO41572	UCEC	ICGC	PYPTPSWS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SCF_FBW7_1	1269:1276	PYPTPSWS	FBXW7	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons