DegronMD

Uniprot ID: O14559

Source protein: Rho GTPase-activating protein 33

Source gene: ARHGAP33

Class: DEG_SCF_FBW7_1

Location: 822:827

E3 ligase: FBXW7

DEGRON score: 0.9733

ASA_SCORE: 85.45

COIL: 0.9627

CONS_SCORE: 0.359

DSS_SCORE: 0.5631

HELIX: 0.014

FCONS_SCORE: 1.0205

RIG_SCORE: 0.6577

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A836P	TCGA-20-1685	OV	TCGA	PTPALS	DEG_SCF_FBW7_1	0.0833
p.L818R	TCGA-69-8255	LUAD	TCGA	PTPALS	DEG_SCF_FBW7_1	0.2222
p.D815Y	TCGA-AA-3955	COAD	TCGA	PTPALS	DEG_SCF_FBW7_1	0.1389
p.R823Q	TCGA-B5-A11Z	UCEC	TCGA	PTPALS	DEG_SCF_FBW7_1	0.7329
p.R823Q	SIDM00525	Osteosarcoma	GDSC	PTPALS	DEG_SCF_FBW7_1	0.7329
p.R823Q	ACH-000359	Bone Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	0.7329
p.R823Q	MG-63	bone	COSMIC	PTPALS	DEG_SCF_FBW7_1	0.7329
p.S814G	TCGA-EE-A2MT	SKCM	TCGA	PTPALS	DEG_SCF_FBW7_1	0.1111
p.R820M	TCGA-EO-A22R	UCEC	TCGA	PTPALS	DEG_SCF_FBW7_1	0.2778
p.S813N	DO222794	COCA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.0833
p.G824A	DO229005	COCA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.754
p.S831I	DO50733	ORCA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.2222
p.R830Q	DO232040	ORCA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.25
p.G829E	DO37130	READ	ICGC	PTPALS	DEG_SCF_FBW7_1	0.2778
p.R833C	DO43843	UCEC	ICGC	PTPALS	DEG_SCF_FBW7_1	0.1667
p.N818H	H2369	pleura	COSMIC	PTPALS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SCF_FBW7_1	822:827	PTPALS	FBXW7	0.9733	More...
Q16891	MICOS complex subunit MIC60	DEG_SCF_FBW7_1	181:186	PTPALS	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons