DegronMD

Uniprot ID: Q16891

Source protein: MICOS complex subunit MIC60

Source gene: IMMT

Class: DEG_SCF_FBW7_1

Location: 181:186

E3 ligase: FBXW7

DEGRON score: 0.9922

ASA_SCORE: 80.4

COIL: 0.8518

CONS_SCORE: 0.3367

DSS_SCORE: 0.7775

HELIX: 0.1228

FCONS_SCORE: 1.0007

RIG_SCORE: 0.6006

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E171Q	DO6186	BRCA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.0556
p.A180D	DO10068	COAD	ICGC	PTPALS	DEG_SCF_FBW7_1	0.75
p.T184N	DO229028	LICA	ICGC	PTPALS	DEG_SCF_FBW7_1	0.7055
p.G177V	SIDM00094	Kidney Carcinoma	GDSC	PTPALS	DEG_SCF_FBW7_1	0.2222
p.G177V	ACH-002199	Kidney Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	0.2222
p.G177V	SN12C	kidney	COSMIC	PTPALS	DEG_SCF_FBW7_1	0.2222
p.G179R	SIDM00140	Melanoma	GDSC	PTPALS	DEG_SCF_FBW7_1	0.2778
p.G179R	ACH-000968	Skin Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	0.2778
p.G179R	COLO-792	skin	COSMIC	PTPALS	DEG_SCF_FBW7_1	0.2778
p.S176R	MDA-MB-361	breast	COSMIC	PTPALS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SCF_FBW7_1	822:827	PTPALS	FBXW7	0.9733	More...
Q16891	MICOS complex subunit MIC60	DEG_SCF_FBW7_1	181:186	PTPALS	FBXW7	0.9922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons