DegronMD - Q16891(IMMT)

IMMT

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E171Q	DO6186	BRCA	ICGC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.0556
p.A180D	DO10068	COAD	ICGC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation blocking ubiquitination signal	0.75
p.A180D	DO10068	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	189:193	Mutation blocking ubiquitination signal	0.5278
p.T184N	DO229028	LICA	ICGC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation altering degron motif	0.7055
p.G177V	SIDM00094	Kidney Carcinoma	GDSC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2222
p.G177V	ACH-002199	Kidney Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2222
p.G177V	SN12C	kidney	COSMIC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2222
p.G179R	SIDM00140	Melanoma	GDSC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2778
p.G179R	SIDM00140	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0556
p.G179R	ACH-000968	Skin Cancer	CCLE	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2778
p.G179R	ACH-000968	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0556
p.G179R	COLO-792	skin	COSMIC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.2778
p.G179R	COLO-792	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	189:193	Mutation rewiring degron network	0.0556
p.S176R	MDA-MB-361	breast	COSMIC	PTPALS	DEG_SCF_FBW7_1	181:186	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc