DegronMD

Uniprot ID: O14559

Source protein: Rho GTPase-activating protein 33

Source gene: ARHGAP33

Class: DEG_SPOP_SBC_1

Location: 658:662

E3 ligase: SPOP

DEGRON score: 0.9958

ASA_SCORE: 80.42

COIL: 0.8704

CONS_SCORE: 0.3734

DSS_SCORE: 0.6172

HELIX: 0.0958

FCONS_SCORE: 1.0753

RIG_SCORE: 0.5754

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R672C	TCGA-DI-A0WH	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.0556
p.S653L	DO48326	ESCA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.R672H	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0556
p.R672H	SIDM01608	Endometrial Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.0556
p.R672H	ACH-000960	Leukemia	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0556
p.R672H	ACH-000990	Endometrial/Uterine Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0556
p.R672H	ACH-001961	Gallbladder Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0556
p.R672H	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.0556
p.A652T	SIDM00690	Head and Neck Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.A652T	SIDM00971	Breast Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.A652T	SIDM01133	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.V667M	SIDM00492	Glioblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.V667M	AM-38	central_nervous_system	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM00316	Glioblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM01372	Pancreatic Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM01394	Kidney Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM01690	Plasma Cell Myeloma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM00173	Head and Neck Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	SIDM00016	Neuroblastoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.P667R	YH-13	central_nervous_system	COSMIC	PHSSS	DEG_SPOP_SBC_1	0.1944
p.L649F	ACH-000401	Skin Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.0833
p.S670G	ACH-000597	Rhabdoid	CCLE	PHSSS	DEG_SPOP_SBC_1	0.1111
p.S670G	ACH-001200	Rhabdoid	CCLE	PHSSS	DEG_SPOP_SBC_1	0.1111
p.A664T	ACH-000999	Colon/Colorectal Cancer	CCLE	PHSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with ARHGAP33 mutations

All proteins holding degron of PHSSS