DegronMD

Uniprot ID: Q8TDJ6

Source protein: DmX-like protein 2

Source gene: DMXL2

Class: DEG_SPOP_SBC_1

Location: 956:960

E3 ligase: SPOP

DEGRON score: 0.985

ASA_SCORE: 67.66

COIL: 0.8446

CONS_SCORE: 0.2362

DSS_SCORE: 0.5729

HELIX: 0.0932

FCONS_SCORE: 0.8217

RIG_SCORE: 0.6331

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L964P	TCGA-23-1124	OV	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2222
p.L964P	DO32596	OV	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2222
p.L964I	TCGA-B5-A0JY	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.2222
p.L964I	DO43041	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2222
p.P950S	TCGA-EE-A29E	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.1667
p.P950S	DO37831	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.1667
p.S958Y	TCGA-EO-A22R	UCEC	TCGA	PHSSS	DEG_SPOP_SBC_1	0.712
p.S958Y	DO42713	UCEC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.712
p.S949F	TCGA-FW-A3R5	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	0.5833
p.S949F	DO37406	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.5833
p.S961C	DO481	BLCA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.3056
p.V953A	DO8264	COAD	ICGC	PHSSS	DEG_SPOP_SBC_1	0.25
p.P954T	DO229045	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	0.2778
p.L947Q	DO23344	LINC	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0833
p.H970Y	DO51273	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	0.0556
p.P956T	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.7031
p.P956T	SIDM01133	Other Solid Cancers	GDSC	PHSSS	DEG_SPOP_SBC_1	0.7031
p.P956T	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	PHSSS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14559	Rho GTPase-activating protein 33	DEG_SPOP_SBC_1	658:662	PHSSS	SPOP	0.9958	More...
O60229	Kalirin	DEG_SPOP_SBC_1	732:736	PHSSS	SPOP	0.9258	More...
O75747	Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma	DEG_SPOP_SBC_1	30:34	PHSSS	SPOP	0.9099	More...
O94933	SLIT and NTRK-like protein 3	DEG_SPOP_SBC_1	296:300	PHSSS	SPOP	0.8737	More...
P20930	Filaggrin	DEG_SPOP_SBC_1	3950:3954	PHSSS	SPOP	0.969	More...
P29372	DNA-3-methyladenine glycosylase	DEG_SPOP_SBC_1	45:49	PHSSS	SPOP	0.9962	More...
P48436	Transcription factor SOX-9	DEG_SPOP_SBC_1	212:216	PHSSS	SPOP	0.9783	More...
Q02817	Mucin-2	DEG_SPOP_SBC_1	4662:4666	PHSSS	SPOP	0.7998	More...
Q13129	Zinc finger protein Rlf	DEG_SPOP_SBC_1	1828:1832	PHSSS	SPOP	0.9974	More...
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1	DEG_SPOP_SBC_1	944:948	PHSSS	SPOP	0.9376	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	304:308	PHSSS	SPOP	0.9956	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1079:1083	PHSSS	SPOP	0.7902	More...
Q76I76	Protein phosphatase Slingshot homolog 2	DEG_SPOP_SBC_1	1213:1217	PHSSS	SPOP	0.9976	More...
Q8IYI8	Zinc finger protein 440	DEG_SPOP_SBC_1	378:382	PHSSS	SPOP	0.7442	More...
Q8NEL9	Phospholipase DDHD1	DEG_SPOP_SBC_1	802:806	PHSSS	SPOP	0.812	More...
Q8TDJ6	DmX-like protein 2	DEG_SPOP_SBC_1	956:960	PHSSS	SPOP	0.985	More...
Q96G01	Protein bicaudal D homolog 1	DEG_SPOP_SBC_1	957:961	PHSSS	SPOP	0.9246	More...
Q9C0B5	Palmitoyltransferase ZDHHC5	DEG_SPOP_SBC_1	368:372	PHSSS	SPOP	0.9986	More...
Q9HCH0	Nck-associated protein 5-like	DEG_SPOP_SBC_1	424:428	PHSSS	SPOP	0.8761	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SPOP_SBC_1	74:78	PHSSS	SPOP	0.969	More...
Q5VYM1	Uncharacterized protein C9orf131	DEG_SPOP_SBC_1	840:844	PHSSS	SPOP	0.8857	More...
Q9P1A2	Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like	DEG_SPOP_SBC_1	345:349	PHSSS	SPOP	0.5244	More...
Q9H6K5	Proline-rich protein 36	DEG_SPOP_SBC_1	357:361	PHSSS	SPOP	0.9525	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PHSSS

Degron related mutations and impact score

Drug responses associated with DMXL2 mutations

All proteins holding degron of PHSSS