DegronMD - Q9UIF9(BAZ2A)

FUNCTION: Regulatory subunit of the ATP-dependent NoRC-1 and NoRC-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:28801535). Both complexes ... View more >>

GO - Biological processes (BP): chromatin remodeling [GO:0006338]; DNA methylation [GO:0006306]; histone deacetylation [GO:0016575]; rDNA heterochromatin assembly [GO:0000183]; regulation of transcription, DNA-templated [GO:0006355]; RNA polymerase I preinitiation complex assembly [GO:0001188]; transcription, DNA-templated [GO:000... View more >>

GO - Molecular function (MF): DNA binding [GO:0003677]; histone binding [GO:0042393]; lysine-acetylated histone binding [GO:0070577]; metal ion binding [GO:0046872]; nuclear receptor binding [GO:0016922]; RNA binding [GO:0003723]

GO - Cellular component (CC): chromatin silencing complex [GO:0005677]; cytosol [GO:0005829]; nuclear speck [GO:0016607]; nucleolus [GO:0005730]; rDNA heterochromatin [GO:0033553]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S28F	TCGA-D3-A3MV	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7982
p.S28F	DO37727	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7982
p.L31P	OVCAR-3	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7582
p.S78C	DO228297	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation altering degron motif	0.7541
p.D289N	KYSE-220	oesophagus	COSMIC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.6932
p.P271S	TCGA-IH-A3EA	SKCM	TCGA	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P271S	DO37667	SKCM	ICGC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P271S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.S26P	SIDM02050	Colorectal Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.6752
p.P273S	SIDM00007	Other Solid Cancers	GDSC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P273S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.S1292R	DO229028	LICA	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation altering degron motif	0.6316
p.V266F	DO234220	ESAD	ICGC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.5957
p.S67L	TCGA-DD-AADP	LIHC	TCGA	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation blocking phosphorylation signal	0.5833
p.S67L	DO52243	LIHC	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation blocking phosphorylation signal	0.5833
p.D290E	DO229041	LICA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.5647
p.Q287K	TCGA-D8-A1JK	BRCA	TCGA	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.Q287K	DO3880	BRCA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.P1294L	TCGA-DX-AB2E	SARC	TCGA	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.3056
p.P1294L	DO220073	SARC	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.3056

Showing 1 to 20 of 65 entries

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Kaplan plot for BAZ2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAZ2A

UniProt ID: Q9UIF9

Entrez ID: 11176

Protein name: Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAZ2A in