DegronMD - Q9UIF9(BAZ2A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1300D	TCGA-06-5416	GBM	TCGA	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1389
p.A1300D	DO10880	GBM	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1389
p.H1279R	TCGA-2Y-A9GS	LIHC	TCGA	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1111
p.T65A	TCGA-77-A5G3	LUSC	TCGA	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.0833
p.T65A	DO45456	LUSC	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.0833
p.G37R	TCGA-B5-A3FC	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.1667
p.G37R	DO41871	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.1667
p.G68V	TCGA-BF-A1Q0	SKCM	TCGA	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.G68V	DO47374	SKCM	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.S28F	TCGA-D3-A3MV	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7982
p.S28F	DO37727	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7982
p.Q287K	TCGA-D8-A1JK	BRCA	TCGA	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.Q287K	DO3880	BRCA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.3056
p.S67L	TCGA-DD-AADP	LIHC	TCGA	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation blocking phosphorylation signal	0.5833
p.S67L	DO52243	LIHC	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation blocking phosphorylation signal	0.5833
p.P1294L	TCGA-DX-AB2E	SARC	TCGA	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.3056
p.P1294L	DO220073	SARC	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.3056
p.S282L	TCGA-E5-A4U1	BLCA	TCGA	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0833
p.S282L	TCGA-E5-A4U1	BLCA	TCGA	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1667
p.S282L	DO44061	BLCA	ICGC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0833
p.S282L	DO44061	BLCA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1667
p.P271S	TCGA-IH-A3EA	SKCM	TCGA	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P271S	DO37667	SKCM	ICGC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P271S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P1299T	TCGA-L5-A4OI	ESCA	TCGA	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1667
p.S86R	DO222765	COCA	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.S86R	DO228976	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.V266F	DO234220	ESAD	ICGC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.5957
p.S78C	DO228297	LICA	ICGC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation altering degron motif	0.7541
p.S1280R	DO228976	LICA	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1389
p.S1292R	DO229028	LICA	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation altering degron motif	0.6316
p.N303K	DO229037	LICA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation rewiring degron network	0.1111
p.D290E	DO229041	LICA	ICGC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.5647
p.H1277R	DO219505	LIHC	ICGC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.0556
p.S26P	SIDM02050	Colorectal Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.6752
p.S1280N	SIDM00845	Burkitt's Lymphoma	GDSC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1389
p.S86N	SIDM00845	Burkitt's Lymphoma	GDSC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.S86N	Daudi	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.S86N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.P273S	SIDM00007	Other Solid Cancers	GDSC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P273S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation altering degron motif	0.6752
p.P257L	SIDM00155	Head and Neck Carcinoma	GDSC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.1111
p.P257L	PCI-38	upper aerodigestive tract	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.1111
p.P257S	SIDM00155	Head and Neck Carcinoma	GDSC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.1111
p.P257S	PCI-38	upper aerodigestive tract	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.1111
p.L33P	SIDM00105	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.L33P	SIDM00093	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.L33P	ACH-000001	Ovarian Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.L33P	ACH-000013	Ovarian Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.L33P	OVCAR-3	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation rewiring degron network	0.2778
p.N71Y	SIDM01573	Plasma Cell Myeloma	GDSC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.25
p.Q1301H	ACH-000017	Breast Cancer	CCLE	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1111
p.Q1301H	ACH-000248	Breast Cancer	CCLE	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1111
p.Q1301H	AU565	breast	COSMIC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.1111
p.N69Y	ACH-000576	Myeloma	CCLE	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1944
p.S84N	ACH-000786	Lymphoma	CCLE	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.S84N	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.S84N	Daudi	haematopoietic and lymphoid tissue	COSMIC	PHSSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.P255L	ACH-002296	Head and Neck Cancer	CCLE	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0556
p.P255L	PCI-38	upper aerodigestive tract	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0556
p.P255S	ACH-002296	Head and Neck Cancer	CCLE	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0556
p.P255S	PCI-38	upper aerodigestive tract	COSMIC	EVSVLVPDP	DEG_COP1_1	265:273	Mutation rewiring degron network	0.0556
p.D289N	KYSE-220	oesophagus	COSMIC	LEDTPILS	DEG_SCF_FBW7_1	288:295	Mutation altering degron motif	0.6932
p.L31P	OVCAR-3	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	26:31	Mutation altering degron motif	0.7582
p.Q1303H	AU565	breast	COSMIC	VLTPDSS	DEG_SCF_FBW7_1	1287:1293	Mutation rewiring degron network	0.0556

Kaplan plot for BAZ2A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAZ2A

UniProt ID: Q9UIF9

Entrez ID: 11176

Protein name: Bromodomain adjacent to zinc finger domain protein 2A (Transcription termination factor I-interacting protein 5) (TTF-I-interacting protein 5) (Tip5) (hWALp3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAZ2A in