DegronMD

Uniprot ID: Q9UIF9

Source protein: Bromodomain adjacent to zinc finger domain protein 2A

Source gene: BAZ2A

Class: DEG_COP1_1

Location: 265:273

E3 ligase: COP1

DEGRON score: 0.9903

ASA_SCORE: 77.3333

COIL: 0.8527

CONS_SCORE: 0.3215

DSS_SCORE: 0.4496

HELIX: 0.0566

FCONS_SCORE: 0.8674

RIG_SCORE: 0.7404

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P271S	TCGA-IH-A3EA	SKCM	TCGA	EVSVLVPDP	DEG_COP1_1	0.6752
p.P271S	DO37667	SKCM	ICGC	EVSVLVPDP	DEG_COP1_1	0.6752
p.P271S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	0.6752
p.P273S	SIDM00007	Other Solid Cancers	GDSC	EVSVLVPDP	DEG_COP1_1	0.6752
p.P273S	MCC13	skin	COSMIC	EVSVLVPDP	DEG_COP1_1	0.6752
p.V266F	DO234220	ESAD	ICGC	EVSVLVPDP	DEG_COP1_1	0.5957
p.P257L	SIDM00155	Head and Neck Carcinoma	GDSC	EVSVLVPDP	DEG_COP1_1	0.1111
p.P257L	PCI-38	upper_aerodigestive_tract	COSMIC	EVSVLVPDP	DEG_COP1_1	0.1111
p.P257S	SIDM00155	Head and Neck Carcinoma	GDSC	EVSVLVPDP	DEG_COP1_1	0.1111
p.P257S	PCI-38	upper_aerodigestive_tract	COSMIC	EVSVLVPDP	DEG_COP1_1	0.1111
p.S282L	TCGA-E5-A4U1	BLCA	TCGA	EVSVLVPDP	DEG_COP1_1	0.0833
p.S282L	DO44061	BLCA	ICGC	EVSVLVPDP	DEG_COP1_1	0.0833
p.P255L	ACH-002296	Head and Neck Cancer	CCLE	EVSVLVPDP	DEG_COP1_1	0.0556
p.P255L	PCI-38	upper_aerodigestive_tract	COSMIC	EVSVLVPDP	DEG_COP1_1	0.0556
p.P255S	ACH-002296	Head and Neck Cancer	CCLE	EVSVLVPDP	DEG_COP1_1	0.0556
p.P255S	PCI-38	upper_aerodigestive_tract	COSMIC	EVSVLVPDP	DEG_COP1_1	0.0556

Showing 1 to 16 of 16 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_COP1_1	265:273	EVSVLVPDP	COP1	0.9903	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons