DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
LEDTPILS
Uniprot ID:
Q9UIF9
Source protein:
Bromodomain adjacent to zinc finger domain protein 2A
Source gene:
BAZ2A
Class:
DEG_SCF_FBW7_1
Location:
288:295
E3 ligase:
FBXW7
DEGRON score:
0.9681
ASA_SCORE:
78.1375
COIL:
0.8064
CONS_SCORE:
0.3438
DSS_SCORE:
0.6457
HELIX:
0.1436
FCONS_SCORE:
0.945
RIG_SCORE:
0.7417
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q287K
TCGA-D8-A1JK
BRCA
TCGA
LEDTPILS
DEG_SCF_FBW7_1
0.3056
p.Q287K
DO3880
BRCA
ICGC
LEDTPILS
DEG_SCF_FBW7_1
0.3056
p.S282L
TCGA-E5-A4U1
BLCA
TCGA
LEDTPILS
DEG_SCF_FBW7_1
0.1667
p.S282L
DO44061
BLCA
ICGC
LEDTPILS
DEG_SCF_FBW7_1
0.1667
p.N303K
DO229037
LICA
ICGC
LEDTPILS
DEG_SCF_FBW7_1
0.1111
p.D290E
DO229041
LICA
ICGC
LEDTPILS
DEG_SCF_FBW7_1
0.5647
p.D289N
KYSE-220
oesophagus
COSMIC
LEDTPILS
DEG_SCF_FBW7_1
0.6932
Drug responses associated with BAZ2A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of LEDTPILS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UIF9
Bromodomain adjacent to zinc finger domain protein 2A
DEG_SCF_FBW7_1
288:295
LEDTPILS
FBXW7
0.9681
More...