DegronMD

Uniprot ID: Q9UIF9

Source protein: Bromodomain adjacent to zinc finger domain protein 2A

Source gene: BAZ2A

Class: DEG_SCF_FBW7_1

Location: 1287:1293

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 75.2571

COIL: 0.8797

CONS_SCORE: 0.3896

DSS_SCORE: 0.652

HELIX: 0.0386

FCONS_SCORE: 1.1403

RIG_SCORE: 0.5567

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1292R	DO229028	LICA	ICGC	VLTPDSS	DEG_SCF_FBW7_1	0.6316
p.P1294L	TCGA-DX-AB2E	SARC	TCGA	VLTPDSS	DEG_SCF_FBW7_1	0.3056
p.P1294L	DO220073	SARC	ICGC	VLTPDSS	DEG_SCF_FBW7_1	0.3056
p.P1299T	TCGA-L5-A4OI	ESCA	TCGA	VLTPDSS	DEG_SCF_FBW7_1	0.1667
p.A1300D	TCGA-06-5416	GBM	TCGA	VLTPDSS	DEG_SCF_FBW7_1	0.1389
p.A1300D	DO10880	GBM	ICGC	VLTPDSS	DEG_SCF_FBW7_1	0.1389
p.S1280R	DO228976	LICA	ICGC	VLTPDSS	DEG_SCF_FBW7_1	0.1389
p.S1280N	SIDM00845	Burkitt's Lymphoma	GDSC	VLTPDSS	DEG_SCF_FBW7_1	0.1389
p.H1279R	TCGA-2Y-A9GS	LIHC	TCGA	VLTPDSS	DEG_SCF_FBW7_1	0.1111
p.Q1301H	ACH-000017	Breast Cancer	CCLE	VLTPDSS	DEG_SCF_FBW7_1	0.1111
p.Q1301H	ACH-000248	Breast Cancer	CCLE	VLTPDSS	DEG_SCF_FBW7_1	0.1111
p.Q1301H	AU565	breast	COSMIC	VLTPDSS	DEG_SCF_FBW7_1	0.1111
p.H1277R	DO219505	LIHC	ICGC	VLTPDSS	DEG_SCF_FBW7_1	0.0556
p.Q1303H	AU565	breast	COSMIC	VLTPDSS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_SCF_FBW7_1	1287:1293	VLTPDSS	FBXW7	0.9956	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons