DegronMD

Uniprot ID: Q9UIF9

Source protein: Bromodomain adjacent to zinc finger domain protein 2A

Source gene: BAZ2A

Class: DEG_Kelch_Keap1_1

Location: 26:31

E3 ligase: KEAP1

DEGRON score: 0.9651

ASA_SCORE: 65.8333

COIL: 0.8617

CONS_SCORE: 0.3265

DSS_SCORE: 0.6128

HELIX: 0.0815

FCONS_SCORE: 0.9436

RIG_SCORE: 0.5439

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G37R	TCGA-B5-A3FC	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.G37R	DO41871	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1667
p.S28F	TCGA-D3-A3MV	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.7982
p.S28F	DO37727	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.7982
p.S26P	SIDM02050	Colorectal Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.6752
p.L33P	SIDM00105	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L33P	SIDM00093	Ovarian Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L33P	ACH-000001	Ovarian Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L33P	ACH-000013	Ovarian Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L33P	OVCAR-3	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.L31P	OVCAR-3	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons