DegronMD

Uniprot ID: O60292

Source protein: Signal-induced proliferation-associated 1-like protein 3

Source gene: SIPA1L3

Class: DEG_Kelch_Keap1_1

Location: 451:456

E3 ligase: KEAP1

DEGRON score: 0.9304

ASA_SCORE: 71.2667

COIL: 0.8215

CONS_SCORE: 0.3235

DSS_SCORE: 0.5052

HELIX: 0.0737

FCONS_SCORE: 0.8272

RIG_SCORE: 0.5377

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S454I	DO229025	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.7341
p.E456K	DO222636	ESCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.7022
p.G455S	SIDM00163	Biliary Tract Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.6993
p.P452L	TCGA-32-2616	GBM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.6471
p.P452L	DO13462	GBM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.6471
p.G457V	DO229024	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.3056
p.V449M	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.V449M	ACH-001639	Leukemia	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.V449M	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.2778
p.S448F	TCGA-FS-A4F9	SKCM	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.S448F	DO38069	SKCM	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.25
p.A460T	TCGA-BR-4257	STAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.2222
p.A460T	DO38683	STAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.2222
p.A447P	ACH-001554	Eye Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2222
p.A447P	ACH-001955	Bone Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.2222
p.R446W	DO229346	LAML	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1944
p.A463V	SIDM00901	Endometrial Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.A463V	ACH-000940	Endometrial/Uterine Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.A463V	AN3-CA	endometrium	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	0.1389
p.S443I	DO229026	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.1111
p.V442M	TCGA-86-8358	LUAD	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.0833
p.V442M	TCGA-EO-A22U	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.0833
p.V442M	DO25471	LUAD	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.0833
p.V442M	DO43755	UCEC	ICGC	SPSSGE	DEG_Kelch_Keap1_1	0.0833
p.S465G	TCGA-AP-A054	UCEC	TCGA	SPSSGE	DEG_Kelch_Keap1_1	0.0833

Showing 1 to 25 of 31 entries

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Drug responses associated with SIPA1L3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of SPSSGE

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIF9	Bromodomain adjacent to zinc finger domain protein 2A	DEG_Kelch_Keap1_1	26:31	SPSSGE	KEAP1	0.9651	More...
Q6ZV50	DNA-binding protein RFX8	DEG_Kelch_Keap1_1	8:13	SPSSGE	KEAP1	0.8762	More...
O15457	MutS protein homolog 4	DEG_Kelch_Keap1_1	17:22	SPSSGE	KEAP1	0.9846	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_Kelch_Keap1_1	717:722	SPSSGE	KEAP1	0.9938	More...
O60292	Signal-induced proliferation-associated 1-like protein 3	DEG_Kelch_Keap1_1	451:456	SPSSGE	KEAP1	0.9304	More...
A8MU46	Smoothelin-like protein 1	DEG_Kelch_Keap1_1	320:325	SPSSGE	KEAP1	0.8915	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SPSSGE

Degron related mutations and impact score

Drug responses associated with SIPA1L3 mutations

All proteins holding degron of SPSSGE