DegronMD - A8MU46(SMTNL1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D312G	DO229010	COCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.1111
p.D312Y	DO228948	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.1111
p.S334I	DO228952	LICA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.0833
p.G317E	DO222402	MELA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.25
p.P328H	DO229229	THCA	ICGC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.25
p.G324A	SIDM00947	Glioblastoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation altering degron motif	0.754
p.G324A	ACH-000244	Brain Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation altering degron motif	0.754
p.G324A	DK-MG	central nervous system	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation altering degron motif	0.754
p.P318S	SIDM00628	Breast Carcinoma	GDSC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.2778
p.P318S	ACH-000849	Breast Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.2778
p.P318S	MDA-MB-468	breast	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.2778
p.R312H	ACH-000986	Colon/Colorectal Cancer	CCLE	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.1111
p.R312H	HT-115	large intestine	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.1111
p.V335I	ACH-001991	Primary	CCLE	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.0556
p.R331H	IGROV-1	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.1667
p.V316M	TOV-21G	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.2222
p.T327M	EFO-27	ovary	COSMIC	SPSSGE	DEG_Kelch_Keap1_1	320:325	Mutation rewiring degron network	0.2778

Kaplan plot for SMTNL1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMTNL1

UniProt ID: A8MU46

Entrez ID: 219537

Protein name: Smoothelin-like protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMTNL1 in